
Contents
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Author Note Author Note
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Introduction Introduction
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Aims of This Chapter Aims of This Chapter
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The Neuroanatomy of OCRDs The Neuroanatomy of OCRDs
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Contemporary Neuroanatomical Models of OCRDs Contemporary Neuroanatomical Models of OCRDs
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Approaches and Methods in Neuroimaging Approaches and Methods in Neuroimaging
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Understanding OCRDs Using the Right Study Design Understanding OCRDs Using the Right Study Design
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Key Findings in OCD Key Findings in OCD
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Structural Studies Structural Studies
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Functional Studies Functional Studies
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Cognitive Paradigms Cognitive Paradigms
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Emotional Paradigms Emotional Paradigms
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Habit Formation Habit Formation
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Emotional Interference Emotional Interference
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Resting State Resting State
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Treatment Studies Treatment Studies
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Neurochemical Studies Neurochemical Studies
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Conclusion for OCD Conclusion for OCD
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Key Findings in Hoarding Disorder Key Findings in Hoarding Disorder
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Structural Studies Structural Studies
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Functional Studies Functional Studies
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Cognitive Paradigms Cognitive Paradigms
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Emotional Paradigms Emotional Paradigms
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Resting State Resting State
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Conclusion for Hoarding Disorder Conclusion for Hoarding Disorder
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Key Findings in BDD Key Findings in BDD
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Structural Studies Structural Studies
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Functional Studies Functional Studies
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Emotional Paradigms Emotional Paradigms
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Resting-State and Treatment Studies Resting-State and Treatment Studies
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Neurochemical Studies Neurochemical Studies
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Conclusion for BDD Conclusion for BDD
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Key Findings in SPD and Trichotillomania Key Findings in SPD and Trichotillomania
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Structural Studies Structural Studies
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Functional Studies Functional Studies
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Cognitive Paradigms Cognitive Paradigms
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Emotional Paradigms Emotional Paradigms
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Resting State Resting State
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Neurochemical Studies Neurochemical Studies
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Conclusions for SPD and Trichotillomania Conclusions for SPD and Trichotillomania
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OCRDs and Anxiety Disorders OCRDs and Anxiety Disorders
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Structural Studies Structural Studies
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Functional Studies Functional Studies
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Conclusion for OCRDs and Anxiety Disorders Conclusion for OCRDs and Anxiety Disorders
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Future Directions Future Directions
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Improving How and What We Measure Improving How and What We Measure
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Improving Transparency and Replicability in Neuroscience Improving Transparency and Replicability in Neuroscience
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Improving Treatments Through Neuroscience Improving Treatments Through Neuroscience
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Conclusions Conclusions
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References References
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7 Neuroanatomy of Obsessive-Compulsive and Related Disorders
Get accessAnders Lillevik Thorsen, Ph.D., Haukeland University Hospital, University of Bergen, and Vrije Universiteit Amsterdam
Odile A. van den Heuvel, MD, Ph.D., Haukeland University Hospital and Vrije Universiteit Amsterdam
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Published:16 August 2023
Cite
Abstract
The structure, function, and chemistry of the brain in obsessive-compulsive and related disorders (OCRDs), and obsessive-compulsive disorder in particular, have long been the topic of scientific inquiry. Current findings suggest that OCRDs share alterations in frontolimbic, frontostriatal, and frontoparietal circuits related to emotional, cognitive, and sensorimotor processing. Ongoing research is focused on combining imaging modalities to better understand the complexity of the brain, as well as how to translate neurobiological findings into treatment innovations. New research is also employing increased rigor and attempts to increase replicability through larger sample sizes and forming a consensus on how to image and analyze the brain.
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