
Contents
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White Matter Connections in the Normal Brain White Matter Connections in the Normal Brain
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Neurodegenerative Disorders Neurodegenerative Disorders
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Alzheimer’s Disease Alzheimer’s Disease
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Frontotemporal Dementia Frontotemporal Dementia
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Parkinson Disease Parkinson Disease
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Multiple Sclerosis Multiple Sclerosis
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Acquired Neurological Disorders Acquired Neurological Disorders
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Apraxia Apraxia
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Aphasia Aphasia
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Agnosia Agnosia
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Amnesia Amnesia
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Traumatic Brain Injury Traumatic Brain Injury
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Psychiatric Disorders Psychiatric Disorders
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Obsessive-Compulsive Disorder Obsessive-Compulsive Disorder
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Depression Depression
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Bipolar Disorder Bipolar Disorder
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Schizophrenia Schizophrenia
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Alcoholism Alcoholism
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References References
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8 White Matter Connectivity
Get accessAntony Passaro, DCS Corporation, Alexandria, Virginia
Foteini Christidi, Postgraduate Program in Clinical Neuropsychology, Medical School, National and Kapodistrian University, Athens, Greece
Vasiliki Tsirka, Department of Clinical Neurophysiology, St. Thomas' Hospital, London, England
Andrew C. Papanicolaou is Professor, Department of Pediatrics, Division of Clinical Neurosciences, and Department of anatomy and neurobiology, University of Tennessee Health Science Center; Neuroscience Institute, Le Bonheur Children's Hospital, Memphis, TN.
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Published:04 August 2014
Cite
Abstract
The applications of diffusion tensor imaging (DTI) have increased considerably among both normal and diverse neuropsychiatric populations in recent years. In this chapter, the authors examine the contributions of DTI in identifying profiles of trait-specific connectivity in several groups defined in terms of gender, age, handedness, and general intelligence. Additionally, the DTI literature is reviewed across a range of neurodegenerative disorders including Alzheimer’s disease, mild cognitive impairment, frontotemporal dementia, Parkinson disease, multiple sclerosis, and acquired neurological disorders resulting from neuronal injury such as traumatic brain injury, aphasia, agnosia, amnesia, and apraxia. DTI metrics sensitive to psychiatric disorders encompassing obsessive-compulsive disorder, depression, bipolar disorder, schizophrenia, and alcoholism are reviewed. Future uses of DTI as a promising means of confirming diagnoses and identifying in vivo early microstructural changes of patients’ clinical symptoms are discussed.
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