
Contents
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Glossary of Technical Terms Glossary of Technical Terms
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Allele Allele
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Chromosome Chromosome
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Endophenotype Endophenotype
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Epigenesis Epigenesis
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Genome Genome
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Genotype Genotype
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Linkage Linkage
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Location of Genes Location of Genes
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Phenotype Phenotype
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Polymorphisms Polymorphisms
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Serotonin Serotonin
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Overview Overview
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How Recognition of Genetic Influence on Eating Disorders Emerged How Recognition of Genetic Influence on Eating Disorders Emerged
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Lack of Evidence to Support Causal Role of Family Environment Lack of Evidence to Support Causal Role of Family Environment
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Consistent Evidence for a Substantial Genetic Contribution to Eating Disorders Consistent Evidence for a Substantial Genetic Contribution to Eating Disorders
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The Complexities of Gene–Environment Interplay The Complexities of Gene–Environment Interplay
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Numerous Genes Acting on Different Pathways Numerous Genes Acting on Different Pathways
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Genetics of Body Mass Index Genetics of Body Mass Index
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Genetics of Behavioral, Temperamental, and Personality Factors Associated with Eating Disorders Genetics of Behavioral, Temperamental, and Personality Factors Associated with Eating Disorders
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Gene–Environment Correlations and Interactions Gene–Environment Correlations and Interactions
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What Twin Studies can Tell Us About Gene–Environment Interplay What Twin Studies can Tell Us About Gene–Environment Interplay
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Why Twin Studies? Why Twin Studies?
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Heritability Estimates Heritability Estimates
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Shared Latent Risk Factors Between Two or More Different Phenotypes Shared Latent Risk Factors Between Two or More Different Phenotypes
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Gene–Environment Interplay Gene–Environment Interplay
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Developmental Changes to Genetic and Environmental Risk Factors Developmental Changes to Genetic and Environmental Risk Factors
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Molecular Genetic Studies: The Current State of Play Molecular Genetic Studies: The Current State of Play
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Identifying Genes Associated with Eating Disorders Identifying Genes Associated with Eating Disorders
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Interactions Between Specific Genetic Variants and Environments Interactions Between Specific Genetic Variants and Environments
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Conclusion Conclusion
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Future Directions Future Directions
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References References
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5 Genetic Influences on Eating Disorders
Get accessTracey D. Wade, School of Psychology, Flinders University, South Australia, Australia
Cynthia M. Bulik Department of Psychiatry School of Medicine University of North Carolina Chapel Hill, NC
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Published:06 September 2017
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Abstract
The current chapter reviews our progress in understanding how genes influence eating disorders by addressing the following areas: (1) how recognition of genetic influences on eating disorders emerged; (2) the complexities of gene environment interplay; (3) what twin studies can tell us about gene environment interplay, and (4) the current state of molecular genetic studies. It is concluded that both genes and nonshared environment play a critical role in the explanatory framework for the etiology of eating disorders. Shared environment is likely to contribute to the development of cognition and attitudes that may initiate disordered eating practices. Researchers are on the cusp of identifying specific genes that are implicated, and explication of the manner in which genes and the environment work together to increase risk for eating disorders hinges on the collection of larger samples.
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