Volume 67, Issue 1
January 2021
Cover image
Cover image
ON THE COVER Heart and blood vessels by da Vinci. Although widely known as a painter, Leonardo da Vinci was also a master of human anatomy. Around 1506, da Vinci dissected a 100-year-old man who had been observed to die suddenly but without any symptoms. Based on an observation of narrowing of the man s coronary arteries, Leonardo s knowledge of both anatomy and hydrodynamics led him to conclude that the cause of death was cardiac failure due to atherosclerosis. It took another 400 years before Nikolai Anichkov, in 1914, showed the significance of increased cholesterol (a biomarker still used today) in the development of atherosclerosis. We are still on a path towards a better understanding of biomarkers of cardiovascular disease, as highlighted by the editorials, interview, reflection, perspective, Q&A, opinions, case study, reviews, point/counterpoint, and research articles in this special issue of Clinical Chemistry. Reproduced with permission from ART Collection / Alamy Stock Photo
ISSN 0009-9147
EISSN 1530-8561
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Volume 67, Issue 1, January 2021
Preamble
Biomarkers in Cardiovascular Disease: Utility in Diagnosis, Risk Assessment, and Therapy
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 1–3, https://doi.org/10.1093/clinchem/hvaa295
Editorials
“Rebranding” Natriuretic Peptides
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 4–5, https://doi.org/10.1093/clinchem/hvaa293
Hypertriglyceridemia and Alzheimer Disease: Opening the Mind to New Therapeutic Opportunities
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 6–8, https://doi.org/10.1093/clinchem/hvaa294
Interview
An Interview with Hugo Katus
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 9–18, https://doi.org/10.1093/clinchem/hvaa276
Reflections
HDL in Morbidity and Mortality: A 40+ Year Perspective
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 19–23, https://doi.org/10.1093/clinchem/hvaa148
Cardiovascular Disease in Women: Understanding the Journey
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 24–29, https://doi.org/10.1093/clinchem/hvaa297
Perspective
Worldwide Changes in Total Cholesterol and Non-HDL-Cholesterol Trends Indicate Where the Challenges Are for the Coming Years
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 30–32, https://doi.org/10.1093/clinchem/hvaa246
Q&A
The Dynamic and Multifaceted Nature of Cardiovascular Disease and Using Genetic Testing to Inform Clinical Care: An International Perspective
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 33–40, https://doi.org/10.1093/clinchem/hvaa251
Opinions
Nonfasting Lipids for All Patients?
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 41–45, https://doi.org/10.1093/clinchem/hvaa195
Being in Two Minds—The Challenge of Heart Failure with Preserved Ejection Fraction Diagnosis with a Single Biomarker
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 46–49, https://doi.org/10.1093/clinchem/hvaa255
Physicians Should Obtain Perioperative Cardiac Troponin Measurements in At-Risk Patients Undergoing Noncardiac Surgery
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 50–53, https://doi.org/10.1093/clinchem/hvaa218
Clinical Case Study
Gastrointestinal Symptoms Followed by Shock in a Febrile 7-Year-Old Child during the COVID-19 Pandemic
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 54–58, https://doi.org/10.1093/clinchem/hvaa279
Commentary on Gastrointestinal Symptoms Followed by Shock in a Febrile 7-Year-Old Child during the COVID-19 Pandemic
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 58–59, https://doi.org/10.1093/clinchem/hvaa291
Commentary on Gastrointestinal Symptoms Followed by Shock in a Febrile 7-Year-Old Child during the COVID-19 Pandemic
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 59–60, https://doi.org/10.1093/clinchem/hvaa292
Mini-Reviews
Type 2 Myocardial Infarction: Evolving Approaches to Diagnosis and Risk-Stratification
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 61–69, https://doi.org/10.1093/clinchem/hvaa189
Implementation of High-Sensitivity and Point-of-Care Cardiac Troponin Assays into Practice: Some Different Thoughts
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 70–78, https://doi.org/10.1093/clinchem/hvaa264
Sodium-Glucose Co-Transporter 2 Inhibitors and Insights from Biomarker Measurement in Heart Failure Patients
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 79–86, https://doi.org/10.1093/clinchem/hvaa277
Biomarkers for Risk Assessment in Atrial Fibrillation
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 87–95, https://doi.org/10.1093/clinchem/hvaa298
Role of Cardiac Biomarkers in Epidemiology and Risk Outcomes
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 96–106, https://doi.org/10.1093/clinchem/hvaa228
Cardiac Troponin Testing in Patients with COVID-19: A Strategy for Testing and Reporting Results
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 107–113, https://doi.org/10.1093/clinchem/hvaa225
Early Rule-Out Strategies in the Emergency Department Utilizing High-Sensitivity Cardiac Troponin Assays
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 114–123, https://doi.org/10.1093/clinchem/hvaa226
Myocardial Injury and the Release of Troponins I and T in the Blood of Patients
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 124–130, https://doi.org/10.1093/clinchem/hvaa281
Reviews
Inflammation in Atherosclerosis—No Longer a Theory
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 131–142, https://doi.org/10.1093/clinchem/hvaa275
Residual Cardiovascular Risk at Low LDL: Remnants, Lipoprotein(a), and Inflammation
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 143–153, https://doi.org/10.1093/clinchem/hvaa252
Lipoprotein(a) and Cardiovascular Disease
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 154–166, https://doi.org/10.1093/clinchem/hvaa247
LDL-Cholesterol versus Glucose in Microvascular and Macrovascular Disease
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 167–182, https://doi.org/10.1093/clinchem/hvaa242
Triglyceride-Rich Lipoprotein Remnants and Cardiovascular Disease
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 183–196, https://doi.org/10.1093/clinchem/hvaa296
Point/Counterpoint
Sex-Specific 99th Percentile URLs for Cardiac Troponin Assays—Their Time Has Come
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 197–200, https://doi.org/10.1093/clinchem/hvaa204
Concerns about Using Sex-Specific Cutoffs for Cardiac Troponin Testing
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 201–203, https://doi.org/10.1093/clinchem/hvaa289
Articles
Proteomics and Protein Markers
B-Type Natriuretic Peptide Is Associated with Indices of Left Ventricular Dysfunction in Healthy Subjects from the General Population: The Akershus Cardiac Examination 1950 Study
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 204–215, https://doi.org/10.1093/clinchem/hvaa257
Atrial Fibrillation and the Prognostic Performance of Biomarkers in Heart Failure
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 216–226, https://doi.org/10.1093/clinchem/hvaa287
Cardiac Troponin Composition Characterization after Non ST-Elevation Myocardial Infarction: Relation with Culprit Artery, Ischemic Time Window, and Severity of Injury
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 227–236, https://doi.org/10.1093/clinchem/hvaa231
Optimizing the Use of High-Sensitivity Troponin Assays for the Early Rule-out of Myocardial Infarction in Patients Presenting with Chest Pain: A Systematic Review
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 237–244, https://doi.org/10.1093/clinchem/hvaa280
Lipids, Lipoproteins, and Cardiovascular Risk Factors
Triglycerides as a Shared Risk Factor between Dementia and Atherosclerotic Cardiovascular Disease: A Study of 125 727 Individuals
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 245–255, https://doi.org/10.1093/clinchem/hvaa269
Biological Variation of Cardiac Troponins in Health and Disease: A Systematic Review and Meta-analysis
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 256–264, https://doi.org/10.1093/clinchem/hvaa261
Plasma Ionized Calcium and Risk of Cardiovascular Disease: 106 774 Individuals from the Copenhagen General Population Study
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 265–275, https://doi.org/10.1093/clinchem/hvaa245
Very Low-Density Lipoprotein Cholesterol May Mediate a Substantial Component of the Effect of Obesity on Myocardial Infarction Risk: The Copenhagen General Population Study
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 276–287, https://doi.org/10.1093/clinchem/hvaa290
Epidemiological Studies
Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 288–297, https://doi.org/10.1093/clinchem/hvaa224
High-Sensitivity Cardiac Troponin, Natriuretic Peptide, and Long-Term Risk of Acute Kidney Injury: The Atherosclerosis Risk in Communities (ARIC) Study
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 298–307, https://doi.org/10.1093/clinchem/hvaa288
Laboratory Management
Variability in Cardiac Biomarkers during Hemodialysis: A Prospective Cohort Study
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 308–316, https://doi.org/10.1093/clinchem/hvaa299
Citation Classic
Menopausal Hormone Therapy and Health Outcomes: Is Timing Everything?
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 317–318, https://doi.org/10.1093/clinchem/hvaa286
Letters to the Editor
Impact of Switching Sample Types for High-Sensitivity Cardiac Troponin I Assays in the 0/1 Hour Algorithms
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 319–321, https://doi.org/10.1093/clinchem/hvaa191
Sex-Specific Kinetics of High-Sensitivity Cardiac Troponin I and T following Symptom Onset and Early Presentation in Non-ST-Segment Elevation Myocardial Infarction
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 321–324, https://doi.org/10.1093/clinchem/hvaa263
Ten Years of High-Sensitivity Cardiac Troponin Testing: Impact on the Diagnosis of Myocardial Infarction
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 324–326, https://doi.org/10.1093/clinchem/hvaa272
Clinical Chemist
Genetic Metabolic Series
Hyperammonemia, Lactic Acidosis, and Arrhythmia in a Newborn
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 327–330, https://doi.org/10.1093/clinchem/hvaa151
Looking to the Past
The Paintsville Heart Study
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 331–332, https://doi.org/10.1093/clinchem/hvaa192
Unveiling the Right Side
The Ballad of the Cardiac Troponins
Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 333–334, https://doi.org/10.1093/clinchem/hvaa167
