Volume 62, Issue 1, 1 January 2016

Preamble

Clinical Mass Spectrometry—Achieving Prominence in Laboratory Medicine

Thomas M Annesley and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 1–3, https://doi.org/10.1373/clinchem.2015.251272

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Editorials

Putting Designer Drugs Back in Pandora's Box: Analytical Challenges and Metabolite Identification

Svante Vikingsson and Henrik Gréen

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 4–5, https://doi.org/10.1373/clinchem.2015.248096

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The Power of Mass Spectroscopy as Arbiter for Immunoassays

Roger Bouillon

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 6–8, https://doi.org/10.1373/clinchem.2015.248484

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Protein-Specific Glycoprofiling for Patient Diagnostics

Dirk J Lefeber

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 9–11, https://doi.org/10.1373/clinchem.2015.248518

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Interview

An Interview with David Millington

Misia Landau

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 12–19, https://doi.org/10.1373/clinchem.2015.238584

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Reflection

Evolution of Quantitative MALDI-TOF Mass Spectrometry for Clinical Applications

Marvin L Vestal

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 20–23, https://doi.org/10.1373/clinchem.2015.239467

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Perspective

CLSI C62-A: A New Standard for Clinical Mass Spectrometry

Kara L Lynch

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 24–29, https://doi.org/10.1373/clinchem.2015.238626

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Q&A

A Spectrum of Views on Clinical Mass Spectrometry

Thomas Annesley and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 30–36, https://doi.org/10.1373/clinchem.2015.250258

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Clinical Case Study

Be Serious: Posttraumatic Endophthalmitis

Allison R McMullen and Carey-Ann D Burnham

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 37–39, https://doi.org/10.1373/clinchem.2015.242016

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Commentary

Christina Wojewoda

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 39–40, https://doi.org/10.1373/clinchem.2015.248419

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Commentary

Nancy S Miller

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Page 40, https://doi.org/10.1373/clinchem.2015.248427

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Special Reports

US Food and Drug Administration Perspectives on Clinical Mass Spectrometry

Julia Tait Lathrop and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 41–47, https://doi.org/10.1373/clinchem.2015.244731

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Recommendations for the Generation, Quantification, Storage, and Handling of Peptides Used for Mass Spectrometry–Based Assays

Andrew N Hoofnagle and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 48–69, https://doi.org/10.1373/clinchem.2015.250563

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Mini-Reviews

Mass Spectrometry in Precision Medicine: Phenotypic Measurements Alongside Pharmacogenomics

Nigel J Clarke

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 70–76, https://doi.org/10.1373/clinchem.2015.239475

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Systems-Wide High-Dimensional Data Acquisition and Informatics Using Structural Mass Spectrometry Strategies

Stacy D Sherrod and John A McLean

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 77–83, https://doi.org/10.1373/clinchem.2015.238261

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Potential of Mass Spectrometry in Developing Clinical Laboratory Biomarkers of Nonvolatiles in Exhaled Breath

Olof Beck and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 84–91, https://doi.org/10.1373/clinchem.2015.239285

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Reviews

Effective Use of Mass Spectrometry in the Clinical Laboratory

Paul J Jannetto and Robert L Fitzgerald

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 92–98, https://doi.org/10.1373/clinchem.2015.248146

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Ambient Ionization Mass Spectrometry for Point-of-Care Diagnostics and Other Clinical Measurements

Christina R Ferreira and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 99–110, https://doi.org/10.1373/clinchem.2014.237164

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Ambient Ionization Mass Spectrometry for Cancer Diagnosis and Surgical Margin Evaluation

Demian R Ifa and Livia S Eberlin

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 111–123, https://doi.org/10.1373/clinchem.2014.237172

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Ion Mobility in Clinical Analysis: Current Progress and Future Perspectives

Christopher D Chouinard and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 124–133, https://doi.org/10.1373/clinchem.2015.238840

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Applications of MALDI Mass Spectrometry in Clinical Chemistry

Mark W Duncan and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 134–143, https://doi.org/10.1373/clinchem.2015.239491

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Automatic Processing of Chromatograms in a High-Throughput Environment

Fred E Lytle and Randall K Julian

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 144–153, https://doi.org/10.1373/clinchem.2015.238816

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Opinion

Mass Spectrometry Selectivity, Specifically

Brian A Rappold

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 154–156, https://doi.org/10.1373/clinchem.2015.240614

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Articles

Drug Monitoring and Toxicology

High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes

Xingxing Diao and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 157–169, https://doi.org/10.1373/clinchem.2015.243535

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Comparison of Information-Dependent Acquisition on a Tandem Quadrupole TOF vs a Triple Quadrupole Linear Ion Trap Mass Spectrometer for Broad-Spectrum Drug Screening

Katie L Thoren and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 170–178, https://doi.org/10.1373/clinchem.2015.241315

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Proteomics and Protein Markers

Measurement by a Novel LC-MS/MS Methodology Reveals Similar Serum Concentrations of Vitamin D–Binding Protein in Blacks and Whites

Clark M Henderson and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 179–187, https://doi.org/10.1373/clinchem.2015.244541

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Automated Multiplex LC-MS/MS Assay for Quantifying Serum Apolipoproteins A-I, B, C-I, C-II, C-III, and E with Qualitative Apolipoprotein E Phenotyping

Irene van den Broek and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 188–197, https://doi.org/10.1373/clinchem.2015.246702

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An Empirical Approach to Signature Peptide Choice for Selected Reaction Monitoring: Quantification of Uromodulin in Urine

Qin Fu and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 198–207, https://doi.org/10.1373/clinchem.2015.242495

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Pediatric Clinical Chemistry

A Novel N-Tetrasaccharide in Patients with Congenital Disorders of Glycosylation, Including Asparagine-Linked Glycosylation Protein 1, Phosphomannomutase 2, and Mannose Phosphate Isomerase Deficiencies

Wenyue Zhang and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 208–217, https://doi.org/10.1373/clinchem.2015.243279

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Endocrinology and Metabolism

LC-MS/MS Measurement of Parathyroid Hormone–Related Peptide

Mark M Kushnir and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 218–226, https://doi.org/10.1373/clinchem.2015.244012

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Multiplexed Quantification of Proglucagon-Derived Peptides by Immunoaffinity Enrichment and Tandem Mass Spectrometry after a Meal Tolerance Test

Anita Y H Lee and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 227–235, https://doi.org/10.1373/clinchem.2015.244251

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LC-MS/MS for Identifying Patients with CYP24A1 Mutations

Hemamalini Ketha and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 236–242, https://doi.org/10.1373/clinchem.2015.244459

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Cancer Diagnostics

Clonotypic Light Chain Peptides Identified for Monitoring Minimal Residual Disease in Multiple Myeloma without Bone Marrow Aspiration

H Robert Bergen and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 243–251, https://doi.org/10.1373/clinchem.2015.242651

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Quantification of Anaplastic Lymphoma Kinase Protein Expression in Non–Small Cell Lung Cancer Tissues from Patients Treated with Crizotinib

Todd Hembrough and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 252–261, https://doi.org/10.1373/clinchem.2015.245860

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Automation and Analytical Techniques

Candidate Reference Measurement Procedure for the Quantification of Total Serum Cortisol with LC-MS/MS

James M Hawley and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 262–269, https://doi.org/10.1373/clinchem.2015.243576

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Planar Functionalized Surfaces for Direct Immunoaffinity Desorption/Ionization Mass Spectrometry

Petr Pompach and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 270–278, https://doi.org/10.1373/clinchem.2015.244004

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Sulfatide Analysis by Mass Spectrometry for Screening of Metachromatic Leukodystrophy in Dried Blood and Urine Samples

Zdenek Spacil and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 279–286, https://doi.org/10.1373/clinchem.2015.245159

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Clinical Immunology

MALDI-TOF-MS Assay to Detect the Hemizygous 22q11.2 Deletion in DNA from Dried Blood Spots

Lisa J Kobrynski and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 287–292, https://doi.org/10.1373/clinchem.2015.247148

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Citation Classic

The Rise of Mass Spectrometry and the Fall of Edman Degradation

Matthias Mann

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 293–294, https://doi.org/10.1373/clinchem.2014.237271

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Letters to the Editor

Rapid Measurement of Cyclosporine and Sirolimus in Whole Blood by Paper Spray–Tandem Mass Spectrometry

Run-Zhang Shi and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 295–297, https://doi.org/10.1373/clinchem.2015.245191

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First Steps toward Harmonization of LC-MS/MS Thyroglobulin Assays

Brian C Netzel and others

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 297–299, https://doi.org/10.1373/clinchem.2015.245266

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Clinical Chemist

Technology Corner

Ambient Ionization: A Dream for the Surgical Oncologist?

Vikram Sheel Kumar and Molly Webster

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 300–301, https://doi.org/10.1373/clinchem.2015.246884

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Unveiling the Right Side

Vitamin D by LC MS MS

Usha Anand

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 302–303, https://doi.org/10.1373/clinchem.2015.246264

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Science in the Arts

Molecular Inspirations

Marek H Dominiczak

Clinical Chemistry, Volume 62, Issue 1, 1 January 2016, Pages 304–306, https://doi.org/10.1373/clinchem.2015.250167

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