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EDITOR'S CHOICE
MIQE 2.0: Revision of the Minimum Information for Publication of Quantitative Real-Time PCR Experiments Guidelines
Stephen A Bustin and others
Clinical Chemistry, hvaf043, https://doi.org/10.1093/clinchem/hvaf043
Published: 24 April 2025
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Accuracy assessment across sites. (A), Summary of assay performance measure...
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Published: 24 April 2025
Fig. 2.
Accuracy assessment across sites. (A), Summary of assay performance measured by recall, precision, and F1 score; (B), Summary of false-positive results across laboratories; (C), False-positive microbes reported among 16 samples; (D), The top 15 false-positive microorganisms with the highest occurren
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Repeatability assessment across laboratories. (A), Repeatability in the det...
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Published: 24 April 2025
Fig. 3.
Repeatability assessment across laboratories. (A), Repeatability in the detection of various microorganisms across 3 replicate samples by 130 laboratories; (B), Repeatability of microbial RPM values across various microorganisms in triplicate samples. *** P < 0.001 by Kruskal–Wallis tests; (C),
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The performance of metagenomic cfDNA sequencing in distinguishing genetical...
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Published: 24 April 2025
Fig. 4.
The performance of metagenomic cfDNA sequencing in distinguishing genetically similar microorganisms. Scatter plots show the RPM value of each microbe reported by laboratories in (A) sample S4 (2-fold change of theoretical ratio 0.17–0.67), (B) S5 (2-fold change of theoretical ratio 0.50–2.00), and
Journal Article
A Comprehensive Assessment of Metagenomic cfDNA Sequencing for Microbe Detection
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Zhenli Diao and others
Clinical Chemistry, hvaf044, https://doi.org/10.1093/clinchem/hvaf044
Published: 24 April 2025
Journal Article
The Need for Better Validation: Evaluating Aptamer and Proximity Extension Assays for Large-Scale Clinical Proteomics Studies
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Andrew N Hoofnagle and Michael J MacCoss
Clinical Chemistry, hvaf046, https://doi.org/10.1093/clinchem/hvaf046
Published: 24 April 2025
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Summary of revisions and updates from previous guidelines ( 3 ).
Published: 24 April 2025
Fig. 1.
Summary of revisions and updates from previous guidelines ( 3 ).
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The multicenter quality assessment study design. In this study, a total of ...
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Published: 24 April 2025
Fig. 1.
The multicenter quality assessment study design. In this study, a total of 18 reference samples were designed and distributed to 130 laboratories. Each laboratory conducted detection using their routine metagenomic cfDNA sequencing procedures and submitted their results to the National Center for Cl
Journal Article
Proteomic Aging Clock Predicts Mortality and Risk of Common Age-Related Diseases
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Zoi E Sychev and Jesse C Seegmiller
Clinical Chemistry, hvaf041, https://doi.org/10.1093/clinchem/hvaf041
Published: 21 April 2025
Journal Article
A Comprehensive Review of Estradiol, Progesterone, Luteinizing Hormone, and Follicle-Stimulating Hormone in the Context of Laboratory Medicine to Support Women's Health
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Dina N Greene and others
Clinical Chemistry, hvaf039, https://doi.org/10.1093/clinchem/hvaf039
Published: 18 April 2025
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Manufacturer-reported reference intervals (represented as bars) or upper re...
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Published: 18 April 2025
Fig. 2.
Manufacturer-reported reference intervals (represented as bars) or upper reference limits (represented by a line) for estradiol (A) and progesterone (B). The values in the brackets are the sample sizes for each specified cycle phase. **Indicates that the bars represent the full range of values and n
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Manufacturer-reported reference intervals for FSH (A) and LH (B). The value...
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Published: 18 April 2025
Fig. 4.
Manufacturer-reported reference intervals for FSH (A) and LH (B). The values in the brackets are the sample sizes for each specified cycle phase. The definition of cycle phases was only described in the package insert corresponding to the Abbott Alinity instrument. **Indicates that the bars represen
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Extracted estradiol reference intervals or limits segregated using cycle-sp...
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Published: 18 April 2025
Fig. 1.
Extracted estradiol reference intervals or limits segregated using cycle-specific values. Sample sizes are listed in brackets when available. Panel A Includes reference intervals or limits from studies reporting cycle non-specific values. Panel B Includes intervals or limits from cycle-specific publ
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Extracted reference intervals for FSH (A) and LH (B) with sample sizes incl...
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Published: 18 April 2025
Fig. 3.
Extracted reference intervals for FSH (A) and LH (B) with sample sizes included in brackets. *Indicates a single study reporting data from different instruments.
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Extracted progesterone reference intervals or limits segregated using cycle...
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Published: 18 April 2025
Fig. 5.
Extracted progesterone reference intervals or limits segregated using cycle-specific values. Sample sizes are listed in brackets when available. Panel A includes reference intervals or limits from studies reporting cycle nonspecific values. Panel B includes intervals or limits from cycle-specific pu
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Estimated percent of healthy US adult males with TT less than 300 ng/dL (10...
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Published: 16 April 2025
Fig. 1.
Estimated percent of healthy US adult males with TT less than 300 ng/dL (10.4 nmol/L) based on National Health and Nutritional Examination Surveys data from 2001–2002, 2003–2004, 2011–2012, 2013–2014, and 2015–2016 cycles.
Journal Article
Reevaluating the Threshold for Low Total Testosterone
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Adith S Arun and others
Clinical Chemistry, hvaf025, https://doi.org/10.1093/clinchem/hvaf025
Published: 16 April 2025
Journal Article
Help Us to Help You: Recommendations for Continued Enforcement Discretion for Common Infectious Disease Test Modifications under the FDA Final Rule
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Kyle G Rodino and others
Clinical Chemistry, hvaf018, https://doi.org/10.1093/clinchem/hvaf018
Published: 16 April 2025
Journal Article
Cardiac Biomarkers in Pulmonary Embolism: Revealing or Redundant?
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A Mark Richards
Clinical Chemistry, hvaf019, https://doi.org/10.1093/clinchem/hvaf019
Published: 16 April 2025
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Instrumentation schematic. The Agilent StreamSelect was configured in share...
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Published: 09 April 2025
Fig. 1.
Instrumentation schematic. The Agilent StreamSelect was configured in shared-stream mode so that calibrators, controls, and samples were split among the 4 LC streams. Created in BioRender. Vac, P. (2025) https://BioRender.com/c61g801 . Color figure available at https://dbpia.nl.go.kr/clinchem
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