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Andrea Rita Horvath, Grading Quality of Evidence and Strength of Recommendations for Diagnostic Tests and Strategies, Clinical Chemistry, Volume 55, Issue 5, 1 May 2009, Pages 853–855, https://doi.org/10.1373/clinchem.2008.117614
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Faced with the plethora of new diagnostic and therapeutic interventions, busy physicians need clear guidance on the best approaches to follow for their patients. This need has led to such a proliferation of practice guidelines (PGs)1 that for diabetes mellitus alone, for example, more than 150 guidelines are available worldwide. In the “jungle” of PGs, many provide conflicting guidance, and the literature displays extensive variation in the approaches to formulating recommendations. Therefore, there is an international move toward standardizing guideline methodology so that recommendations are conceived in a systematic and transparent process and that the link between the evidence and the strength of recommendations is explicitly documented. This commentary provides a brief overview of the principles for assessing the strength of evidence and the challenges guideline developers face in formulating graded recommendations related to the use of laboratory tests.
Guidelines aim to close the gap between research and practice and to provide rigorously developed, valid, and applicable recommendations for achieving the best possible outcomes. The formulation of evidence-based guidelines implies a process in which the body of evidence has been systematically explored, its quality critically evaluated, and the research findings synthesized and translated into recommendations for best practice. In PGs, quality of evidence indicates the degree of confidence that the evidence is adequate to support recommendations. Quality of evidence can be judged by considering the following aspects (1):
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