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Vlad C Vasile, Luciano Babuin, Evangelos Giannitsis, Hugo A Katus, Allan S Jaffe, Relationship of MRI-Determined Infarct Size and cTnI Measurements in Patients with ST-Elevation Myocardial Infarction, Clinical Chemistry, Volume 54, Issue 3, 1 March 2008, Pages 617–619, https://doi.org/10.1373/clinchem.2007.095604
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To the Editor:
The extent of myocardial infarction (MI) is related to patient outcomes (1), and clinicians often wish to have a sense for this critical measure. Imaging methods, although accurate, have limited accessibility and high cost. Thus clinicians often use biomarkers to provide such an estimate. Measurement of cardiac troponin T (cTnT) at 96 h after onset of MI was observed to correlate with MRI-determined infarct size in both ST-elevation MI (STEMI) and non-STEMI (2). We tested the hypothesis that cardiac troponin I (cTnI), another myocardium-specific biomarker, would provide an equivalent estimation in the subset of STEMI patients previously described (2).
The 28 patients with STEMI had sufficient sample remaining to allow for determination of cTnI (2). The characteristics of this group have previously been reported (2), but in brief the mean age (SD) was 56 (11) years, and 17.4% of patients were women. Mean (SD) body mass index was 26.46 (3.5) kg/m2, and 71.4% of patients were hypertensive, 64.3% were current smokers, 60.7% had hypercholesterolemia, and 14.3% had diabetes. Blood samples were available at admission and at 24, 48, 72, and 96 h after onset of symptoms. cTnI concentrations were measured at a laboratory in Heidelberg, Germany, with the AccuTnI assay (Beckman-Coulter). The assay has a limit of detection of 0.01 μg/L, with a 99th percentile as low as 0.02–0.03 μg/L. In the laboratory performing the measurements, a cutoff value of 0.03 μg/L was used. Cardiac MRI was performed as described elsewhere (2). Plasma concentrations of cTnI are reported as median with the corresponding interquartile range (IQR). For all analyses, a value of P <0.05 was considered statistically significant. Correlation coefficients were calculated by the Spearman test.
