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Eckard Wimmer, Emilio A. Emini, Bradford A. Jameson, Peptide Priming of a Poliovirus Neutralizing Antibody Response, Reviews of Infectious Diseases, Volume 6, Issue Supplement_2, May-June 1984, Pages S505–S509, https://doi.org/10.1093/clinids/6.Supplement_2.S505
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Abstract
Two peptides representing neutralizing epitope-containing regions of the capsid protein VPl of type 1 poliovirus were chemically synthesized. Both peptides were found capable of priming rabbits for a significant, long-lasting, anti-virus neutralizing IgG response following a single inoculation of intact virion. In addition, a third synthetic peptide, an extended version of one of the two priming peptides, was capable of eliciting a neutralizing antibody response following inoculation of the carrier-linked peptide alone.