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Fabrice Bonnet, Christine Burty, Charlotte Lewden, Dominique Costagliola, Thierry May, Vincent Bouteloup, Eric Rosenthal, Eric Jougla, Patrice Cacoub, Dominique Salmon, Geneviéve Chéne, Philippe Morlat, Agence Nationale de Recherches sur le Sida et les Hé patites Virales EN19 Mortalité Study Group and the Mortavic Study Group, Changes in Cancer Mortality among HIV-Infected Patients: The Mortalité 2005 Survey, Clinical Infectious Diseases, Volume 48, Issue 5, 1 March 2009, Pages 633–639, https://doi.org/10.1086/596766
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Abstract
Background. The goal of the current study was to describe the distribution and characteristics of malignancy-related deaths among human immunodeficiency virus (HIV)-infected patients with use of data obtained from a national survey conducted in France in 2005 and to compare with results obtained from a similar survey conducted in 2000.
Method. The underlying cause of death was documented using a standardized questionnaire fulfilled in French hospital wards and networks that were involved in the treatment of HIV-infected patients.
Results. Among the 1042 deaths reported in 2005 (964 were reported in 2000), 344 were cancer related (34%), which represented a significant increase from 2000 (29% of deaths were cancer related) (P=.02); 134 of the cancer-related deaths were AIDS related and 210 were not AIDS related. Among the cancer-related causes of death, the proportion of hepatitis-related cancers (6% in 2000 vs. 11% in 2005) and non-AIDS/hepatitis-related cancers (38% in 2000 vs 50% in 2005) significantly increased from 2000 to 2005 (P=.03 and P=.01, respectively), compared with the proportion of cancer that was AIDS related and adjusting for age and sex. Among cases involving AIDS, the proportion of non-Hodgkin lymphoma-associated deaths did not change statistically significantly between 2000 and 2005 (11% and 10% of deaths, respectively).
Conclusions. In this study, an increasing proportion of lethal non-AIDS-related cancers was demonstrated from 2000 to 2005; meanwhile, the proportion of lethal AIDS-related cancers remained stable among HIV-infected patients. Thus, cancer prophylaxis, early diagnosis, and improved management should be included in the routine long-term follow-up of HIV-infected patients.
