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Antonella d'Arminio Monforte, Malignancy-Related Deaths among HIV-Infected Patients, Clinical Infectious Diseases, Volume 48, Issue 5, 1 March 2009, Pages 640–641, https://doi.org/10.1086/596767
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Bonnet et al. [1] have recently published a study on malignancy-related deaths among human immunodeficiency virus (HIV)-infected subjects, comparing data from 2 surveys on deaths conducted in France in 2000 and 2005 (Mortalité 2000 and Mortalité 2005). Globally, in their analysis, malignancies represented the second most common cause of death in 2005, after AIDS-related diseases, and accounted for more than one-third of deaths in the same period. Comparing the 2 surveys, the authors demonstrated an increase in the proportion of malignancy-related deaths and a decrease in the proportion of AIDS-related deaths.
In detail, they outline the increasing prevalence of deaths attributable to non-AIDS-related, non-liver-related, and liver-related cancers between 2000 and 2005, whereas deaths attributable to AIDS-related cancers remained constant. Lung cancer represented the first most common cause of death among non-AIDS-related, non-liver-related cancers in both 2000 and 2005, whereas the relative role of hepatitis B virus (HBV) infection in deaths attributable to liver-related cancers decreased concomitant with an increase in the role of hepatitis C virus (HCV) infection. It was not possible to examine the roles of immunodepression and combination antiretroviral therapy (cART) in this study; the only observation that Bonnet et al. [1] underline is that, despite the increasing percentage of patients receiving cART, the proportion of non-Hodgkin lymphoma did not substantially decrease between 2000 and 2005.
