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Keith Smith, Andrew Small, Michael G Hutchings, Regiospecific Synthesis of 1-Substituted 1,2,4-Triazoles Involving Isomerization of the Corresponding 4-Substituted Compounds, Chemistry Letters, Volume 19, Issue 3, March 1990, Pages 347–350, https://doi.org/10.1246/cl.1990.347
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Abstract
On heating with a catalytic quantity of the corresponding alkyl or phenacyl halides, 4-alkyl- or 4-phenacyl-1,2,4-triazoles isomerize via quaternary salts to their 1-substituted isomers. Thus, the 1-substituted compounds can now be obtained regiospecifically from 1,2,4-triazole by alkylation-isomerization.
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© 1990 The Chemical Society of Japan
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