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Takahiko Akiyama, Masahiro Kumegawa, Yasuhiro Takesue, Hiroyuki Nishimoto, Shoichiro Ozaki, p-Methoxybenzyl as a New N3-Imide Protecting Group of 5-Fluorouridine and Its Application to the Synthesis of 5′-O-Acryloyl-5-fluorouridine, Chemistry Letters, Volume 19, Issue 3, March 1990, Pages 339–342, https://doi.org/10.1246/cl.1990.339
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Abstract
5′-O-Acryloyl-5-fluorouridine was prepared by use of p-methoxybenzyl(PMB) group as a new N3-imide protecting group of 5-fluorouridine. A chemoselective method for protection has been developed by use of ethyldiisopropylamine as a base and deprotection was effected by AlCl3-anisole system.
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© 1990 The Chemical Society of Japan
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