Glial Cell Development: basic principles and clinical relevance
Glial Cell Development: basic principles and clinical relevance
Department of Anatomy and Developmental Biology
MRC Laboratory for Molecular Cell Biology
Cite
Abstract
The majority of cells in the nervous system are glial cells. During development, these cells provide growth factors that stimulate the proliferation, migration, and survival of neurons and their precursors, and promote and guide axonal growth. In the mature nervous system, glial cells provide insulating myelin sheath around axons and provide metabolic and structural support for neurons. Glial cells also have a major influence on the local response to injury of central nerve tracts and the peripheral nervous system, either promoting, or inhibiting, axonal regrowth and recovery of lost function. This book provides a comprehensive overview of research into the development, function, and malfunction of glial cells. It offers a compelling insight into how basic research throws light onto diseases and disorders and points the way towards treatments.
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Front Matter
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1
The Schwann cell lineage: embryonic and early postnatal development
H.J.S. Stewart and others
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2
Developmental origins of astrocytes
James E. Goldman
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3
Origins and early development of oligodendrocytes
William D. Richardson and others
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4
Axonal control of oligodendrocyte development
B.A. Barres andM.C. Raff
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5
Speculations on myelin sheath evolution
D.R. Colman and others
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6
Control of myelin gene expression
Lynn D. Hudson and others
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7
Microglia in the developing and mature central nervous system
V. Hugh Perry
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8
Myelin-specific genes and their mutations in the mouse
Klaus-Armin Nave
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9
Axon–Schwann cell interactions during peripheral nerve degeneration and regeneration
Steven S. Scherer andJames L. Salzer
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10
The role of astrocytes in axon guidance during development and repair
Haila Vickland andJerry Silver
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11
Glial cell transplantation and the repair of demyelinating lesions
William F. Blakemore and others
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12
Transplantation of Schwann cells into the CNS: potential for repair of tract lesions
G. Raisman
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13
The role of glia in the development of the insect nervous system
Vanessa J. Auld
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End Matter
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