Secretory Pathway
Secretory Pathway
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Abstract
This, the latest in the Sambrook and Tooze Guidebook Series enables non-specialists to rapidly gain access to unfamiliar work surrounding the secretory pathways. Detailing both the established and the experimental, this book outlines how recent work has established a role for the secretory pathway in the regulation of gene expression and cell-cycle control, clearly highlighting its importance. Addressing many aspects of the secretory pathway, the book contains almost two hundred entries, and falls in five sections: protein secretion in E.coli; translocation and maturation of newly synthesized polypeptides in the ER of eukaryotic cells; protein machines and catalyzing ER to golgi transport; membrane traffic in the golgi and to the cell surface, and membrane traffic to the lysosome/vacuole. Providing key references in a clear, informative layout, this book provides a valuable guide to the bewildering and complex array of genes and proteins involved in the cellular secretory pathway. The guidebook will maintain up to date entries - the almost two hundred contributors will update their entries continuously, and these updates will be available via the Internet.
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Entering the secretory pathway
Jonathan Rothblatt and others
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The E. coli preprotein translocase
W Wickner
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SRP-like complex in prokaryotes
P Walter
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Sec B
C Kumamoto
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GroEL and GroES
J Martin andF -U Hartl
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SecA
D Oliver
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SecE
A M Flower andT J Silhavy
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SecY
A M Flower andT J Silhavy
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SecD and SecF
K J Pogliano andJ Beckwith
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Leader peptidase
R E Dalbey
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Lipoprotcin signal peptidase
L Isaki andH C Wu
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The E. coli preprotein translocase
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A. Protein Translocation And Maturation In The Yeast Er
J Rothblatt
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SSA Hsp70 subfamily
R J Nelson andE Craig
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SEC65
B J Stirling
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SRP54
C C Hann andP Walter
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SRP101
S C Ogg andP Walter
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SEC61
D J Stirling
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SSS1
E K épe é
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SEC62
R Deshaies
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SEC63
D A Feldheim
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SEC66
D A Fcldheim
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SEC67
D A Feldheim
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SEC70
N Green
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SEC71
N Green
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SEC72
N Green
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SEC11
P B öhni
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KAR2
M Rose andJ P Vogel
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PDI1
M F Tuite andR B Freedman
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EUG1
K Ekena and others
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FKB2
K Sykes
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ERN1
K Mori and others
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SHR3
P O Ljungdahl andG R Fink
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SEC53
F K ép és
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SEC59
G K ép és
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DPM1
P Orlean
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The ALG genes
P W Robbins
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WBP1
M Aebi andS te Heescn
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α,-glucosidase I
R Trimble and others
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ER α,1,2-mannosidase
Herscovics “
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Protein translocation and maturation in the mammalian Er
J Roth blatt
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Signal recognition particle (SRP)
D L Zimmerman andP Walter
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Docking protein/SRP receptor
D I Meyer
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Ribosome receptor
A J Savitz andD I Meyer
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TRAM
E Hartmann andT A Rapoport
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Mammalian Sec61p
E Hartmann andT A Rapoport
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Signal sequence receptor (SSR) complex
E Hartmann andT A Rapoport
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Calnexin
J Bergeron and others
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BiP
M J Gething
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GRP94
M Green
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Calrcticulin
H L E Koch
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7/Protein disulphide isomerase (PDI)
R B Freedman andM F Tuite
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KBP-13
K Sykes
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Microsomal signal peptidase complex
G Shelness
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SPC22/23
G Shelness
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SPC21
G Shclncss
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SPC18
G Shelness
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Oligosaccharide-P-P-dolichol assembly
S S Krag
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N-Acetylglucosaminyl phosphate transferase
S S Krag
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Oligosaccharyltransferase complex
R Gilmore
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Ribophorin I and II
G Kreibich
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OST48
R Gilmore
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N-glycan terocessing in the ER
R Trimbe and others
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α-Glucosidase I
R Trimble and others
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α-Glucosidase II
R Trimble and others
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Ca2+ -dependent a-1,2-mannosidase
R Trimble andK Moremen,and A Herscovics
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A. Protein Translocation And Maturation In The Yeast Er
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Introduction
W E Balch
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SEC12
A Nakano
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SAR1
A Nakano
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SEC16
B Kaiser
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SEC13
N K Pryer
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SEC31
N Salama
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SEC23
L Hicke andR Schekman
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SEC24
T Y oshihisa
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YPT1
N Segev
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ARFl and ARF2
T Stearns andR A Kahn
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SEC21
M Hosolmchi
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BET1
S Ferro-Novick
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BOS1
S Ferro-Novick
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SEC22
S Ferro-Novick
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SLY1
C Daschcr andH D Schmitt
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BET2
S Ferro-Novick
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SEC18
T Graham andS Emr
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SEC17d
¾ C Kaiser
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SEC19
N K Pryer
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ERD2
I Pelham
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SED4
H Pelham
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SED5
H Pelham
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SEC20
H Pelham
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ERGIC-53
H -P Hauri
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p63
H -P Hauri
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Rab1
W E Balch
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Introduction
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Introduction
Peter Novick
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PMR1
A Antebi andG R Fink
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SEC7
A Franzusoff
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SEC14
V Bankaitis
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MNT1
A H äusler andP W Robbins
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Guanosine diphosphatase
B Hirschberg
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KtX1
A Cooper andH Bussey
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KEX2
B Fuller
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STE13
C A Flanagan andJ Thorner
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SEC1
P Novick
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SEC2
P Novick
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SEC4
P Novick
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SEC6
P Novick
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SEC9
V Bankaitis
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SEC15
P Novick
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SNC1 and SNC2
J E Gerst
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ACT1
P Novick
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DSS4
D Roberts andP Novick
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NSF
E W Wilson
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SNAP
M Brunner andS W Whiteheart
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ADP-ribosylation factor (ARF)
R Kahn
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Coatomer
M G Waters andC J M Beckers
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P115
M G Waters
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Mannosidases of the Golgi complex
R B Trimble and others
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Golgi a-mannosidase I
R Trimble and others
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Golgi a-mannosidase II
R Trimble and others
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Golgi endo- α-mannosidase
R G Spiro
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Genes required for the maturation of N-linked carbohydrates in mammalian cells
P Stanley
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Furin
F Thomas
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PC2 and PC3
S Smeckens
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TGN38/41
G Banting and others
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GP-2
M J Rindler
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Rab proteins on the exocytic and endocytic pathway
M Zerial and others
- Rab3 protein family
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Synapsin protein family
R Jahn andT C Südhof
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Synaptobrevin protein family
R Jahn andT C Südhof
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Synaptophysin protein family
R Jahn andT C Südhof
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Synaptotagmin protein family
R Jahn andT C Südhof
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GDI
P Novick
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p145
T J f. martin and others
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Introduction
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Introduction
T H Stevens
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VPS1
C K Raymond andT H Stevens
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VPS3
D K Raymond andT H Stevens
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VPS5
B F Horazdovsky andS D Emr
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VPS8
C K Raymond andT H Stevens
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VPS10
D Marcusson and others
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VPS15
P K Herman and others
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VPS16
B F Horazdosky andS D Emr
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VPS17
J K öhrcr andS D Emr
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V1PS18/PEP3
K S Robinson andS D Emr
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VPS21
C F Horazdovsky and others
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VPS27
C K Raymond andT H Stevens
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VPS28
L K öhrer and others
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VPS33
M M Banta andS D Emr
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VPS34
J H Stack and others
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VPS35
B Horazdovsky and others
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VPS45
R C Piper andT H Stevens
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PEP4
J Winther and others
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PEPS
C A Woolford andE W Jones
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PEP7
J Q Zhang and others
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PEP8
A K Bachhawat andF W Jones
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PEP12
K A Bachhawat andF W Jones
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MVP1
K Ekena andT H Stevens
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VAM7
Y Wada andY Anraku
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VAC2
J Shaw andW Wiclrner
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VMA1
N N Ho andT H Stevens
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VMA2
M N Ho andT H Stevens
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VMA3
M N Ho andT H Stevens
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VMA4
M N Ho andT H Stevens
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VMAS
M N Ho andT H Stevens
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VMA6
B M Bauerle andT H Stevens
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VMA11
Y Ohya and others
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VMA13
M N Ho andT H Stevens
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VPH1
M Manolson and others
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CHG1
H S Payne andS K Lemmon
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CLC1
L Silveira andR Schekman
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END2
C Hamburger and others
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END3,END4
S Raths andH Reizman-
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YPT7
I Wichmann and others
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RENZ
O G Davis andG F Sprague,Jr.
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UDP-N-acety lglucosamine : ly sosomal enzyme N-acetylglucosaminc 1-phosphotransfcrase
D M Ketcham
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N-acetylglucosamine-1-phosphodiestcr —α, N-acety lglucosaminidase
J G Mullis
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Cation-independent mannose 6- phosphate/insulin-like growth factor-· II receptor
W M Canfield
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Cation-dependent mannose 6-phosphatereceptor
K F Johnson
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Clathrin heavy chain
T Kirchhauscn
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Clathrin light chains, LC:a and LCb
U Plcy andP Parham
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Clathrin-associated protein complexes (APs)
T Kirchhausen
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Dynamin (shibire)
R B Vallee
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End3
R K Draper
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End4
R K Draper
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End5
R K Draper
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Rab4
I Mellman
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Rab5
L Zerial
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Rab9
S Pfeffer
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Introduction
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