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15 Hormonal Regulation in in Vitro FertiIization
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Published:January 1993
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Abstract
During the late 1960s Bob Edwards and his colleagues fixed on the idea that in vitro fertilization and embryo transfer in humans would provide enormous therapeutic and scientific opportunities. While this was not altogether a new idea, he, along with the clinician Patrick Steptoe, was-the first to persevere in the face of both peer and public ridicule as well as seemingly insurmountable technical problems. We should recall that, early on, public tolerance for such endeavours was slight indeed. The situation changed dramatically in the summer of 1978 with the birth of Louise Brown in Oldham, England. At last Edwards and Steptoe had succeeded in one case with in vitro fertilization and embryo transfer. While we were all amazed (some were sceptical; others were dubious) at this great achievement, it had arrived not unlike so many other medical advances: that is, through many years of preliminary animal and human studies, ultimately brought to clinical application through heroic effort and rigorous scientific study. But these events are best recorded by Edwards himself. Even so, it must be noted that the practical utility of in vitro fertilization and embryo transfer on a broad scale required radical revisions of the initial procedures in order to achieve anything approaching a reliable treatment. Much of this presentation is taken from earlier summaries (Hodgen, 1986; Veeck, 1986).
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