
Contents
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8 Cervical Cancer Screening and HPV Vaccination: Multilevel Challenges to Cervical Cancer Prevention
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16 Psychosocial Issues Related to Liquid Biopsy for ctDNA in Individuals at Normal and Elevated Risk
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Introduction Introduction
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Defining Cancer-Related Fatigue Defining Cancer-Related Fatigue
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Prevalence of Cancer-Related Fatigue Prevalence of Cancer-Related Fatigue
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Pathophysiology Pathophysiology
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Assessment of Cancer-Related Fatigue Assessment of Cancer-Related Fatigue
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Assessment of Etiologies Assessment of Etiologies
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Assessment Instruments Assessment Instruments
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Fatigue and Depression Fatigue and Depression
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Fatigue and Pain Fatigue and Pain
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Management of Cancer-Related Fatigue Management of Cancer-Related Fatigue
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General Strategies for Management of Fatigue General Strategies for Management of Fatigue
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Nonpharmacologic Interventions Nonpharmacologic Interventions
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Exercise Exercise
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Psychosocial Interventions Psychosocial Interventions
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Mind-Body Interventions Mind-Body Interventions
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Pharmacologic Interventions Pharmacologic Interventions
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Psychostimulants Psychostimulants
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Wakefulness-Promoting Agents Wakefulness-Promoting Agents
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Antidepressants Antidepressants
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Corticosteroids Corticosteroids
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Megestrol Acetate Megestrol Acetate
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L-Carnitine L-Carnitine
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Donepezil Donepezil
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Other Medications Other Medications
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Future Directions Future Directions
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References References
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34 Cancer-Related Fatigue
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Published:January 2021
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Abstract
Cancer-related fatigue (CRF) is abundantly represented in most cancer populations and is highly distressing, causing significant psychological and functional morbidity. It does not receive enough attention from cancer clinicians as a certain amount of fatigue is expected from cancer and treatments. However, CRF is a distinct entity and category of fatigue that does not respond to usual restorative measures. This chapter reviews its definition, prevalence, pathophysiology, and assessment including unique contributory causes and distinguishing CRF from other symptoms such as depression and pain. Measurement tools are discussed. Strategies for the management of CRF including pharmacologic and nonpharmacologic interventions are reviewed and tips are provided. Evidence is presented for the use of psychostimulants and other drug therapy as well as exercise, psychotherapies, and mind-body interventions (e.g., yoga, acupuncture). CRF is a distinct entity with significant consequences for patients. Its assessment should be thorough and treatment directed toward underlying causes.
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