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Introduction Introduction
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Effects of HAART Effects of HAART
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Kaposi’s sarcoma Kaposi’s sarcoma
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Epidemiology and aetiology Epidemiology and aetiology
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Presentation Presentation
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Investigations Investigations
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Pathology Pathology
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Staging Staging
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Management Management
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Local therapy for local control and cosmesis Local therapy for local control and cosmesis
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Systemic therapy Systemic therapy
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HAART HAART
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Chemotherapy Chemotherapy
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Biological therapies Biological therapies
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Supportive care Supportive care
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Systemic non-Hodgkin’s lymphoma Systemic non-Hodgkin’s lymphoma
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Epidemiology and aetiology Epidemiology and aetiology
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Presentation Presentation
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Pathology Pathology
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Investigations and staging Investigations and staging
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Poor prognostic factors Poor prognostic factors
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Management Management
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Primary CNS lymphoma Primary CNS lymphoma
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Epidemiology and aetiology Epidemiology and aetiology
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Presenting symptoms Presenting symptoms
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Pathology Pathology
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Investigations Investigations
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Management Management
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Cervical cancer in HIV-positive females Cervical cancer in HIV-positive females
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Non-AIDS-defining malignancies Non-AIDS-defining malignancies
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Hodgkin’s disease Hodgkin’s disease
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Anal cancer Anal cancer
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Other solid malignancies Other solid malignancies
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Further reading Further reading
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Cite
Extract
Introduction
Human immunodeficiency virus (HIV) represents the worst pandemic of the last quarter of a century.
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Malignant disease is observed in 25–40% of all HIV-infected patients at some stage in their illness and may be causative in almost one-third of HIV-related deaths. Currently four malignancies define the onset of AIDS:
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Other tumours have an increased incidence in HIV-positive individuals, e.g. anal cancer, Hodgkin’s disease, but are not AIDS defining.
Management of the patient with an AIDS-related malignancy requires a multidisciplinary approach with consideration of:
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Effects of HAART
The evolution of highly active antiretroviral therapy (HAART) made it possible to achieve near-complete suppression of viral load and to maintain CD4 lymphocyte counts. Although the death rate from AIDS-related causes in developed countries is falling, an increasing number of deaths in HIV patients can be attributed to non-AIDS-related diseases. Observations have included:
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Kaposi’s sarcoma
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Epidemiology and aetiology
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