
Contents
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Disease Description Disease Description
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Epidemiology Epidemiology
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Presenting Features and Complications Presenting Features and Complications
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Diagnostic Considerations and Tests Diagnostic Considerations and Tests
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Organisms Organisms
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Treatment Treatment
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Additional treatment guidelines Additional treatment guidelines
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Other Key Issues Other Key Issues
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Suggested Readings and References Suggested Readings and References
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Cite
Abstract
Sepsis is a clinical syndrome characterized by systemic inflammation in the presence of infection. The source of infection may be occult. One must be aware of the epidemiology, presenting features and complications, diagnostic considerations and tests, and the organisms involved. Bacteria (gram positive and negative) are most commonly associated with sepsis, although fungi, viruses, and parasites can cause sepsis. Infections in the lungs, urinary tract, abdomen, skin, brain, and other areas can cause bacteremia and lead to sepsis. Treatment includes airway, breathing, and circulation (ABCs) management; aggressive fluid resuscitation; early administration of broad-spectrum antibiotics; and early goal-directed therapy and severe sepsis resuscitation bundle. Diagnosis can be challenging in pediatric and geriatric populations.
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