The OMICs: Applications in Neuroscience
The OMICs: Applications in Neuroscience
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Abstract
This resource summarizes the state of the art in OMICs applications in neurology and neuroscience, attracting neurologists who are interested in the progress of this field towards clinical applications, and neuroscientists who may be not familiar with the most recent advances in this ever-changing field. It includes an overview of most relevant high-throughput approaches (collectively known as 'OMICs') and how they relate to neurology and neuroscience. High-throughput assays have introduced large datasets, computational servers, and bioinformatics approaches to neuroscience and medicine in general. It provides an overview of the application or method, a perspective on the current and future applications in neurology and neuroscience, and a few published examples illustrating possible practical use. Emerging topics such as ethical issues related to personal genome sequencing, epigenetics, network analysis, and role of peripheral biomarkers in disease diagnosis and follow-up are also covered.
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Front Matter
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Part I DNA
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Part II RNA
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4
Transcriptomics
T. Grant Belgard andDaniel H. Geschwind
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5
Decoding Alternative mRNAs in the “Omics” Age
Yuan Yuan andDonny D. Licatalosi
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6
Transcriptomics: From Differential Expression to Coexpression
Michael C. Oldham
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7
High-Throughput RNA Interference as a Tool for Discovery in Neuroscience
Lisa P. Elia andSteven Finkbeiner
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8
The Genetics of Gene Expression: Multiple Layers and Multiple Players
Amanda J. Myers
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4
Transcriptomics
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Part III Protein
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Part IV Cells and Connections
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11
Cellomics: Characterization of Neural Subtypes by High-Throughput Methods and Transgenic Mouse Models
Joseph Dougherty
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12
Neuroscience and Metabolomics
Reza M. Salek
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13
Brain Connectomics in Man and Mouse
Arthur W. Toga and others
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14
Optogenetics
Richie E. Kohman and others
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15
Characterizing the Gut Microbiome: Role in Brain–Gut Function
Gerard Clarke and others
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11
Cellomics: Characterization of Neural Subtypes by High-Throughput Methods and Transgenic Mouse Models
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Part V Therapeutics
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Part VI OMICsOME: Integration of OMICs Data
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End Matter
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