https://orcid.org/0000-0001-8261-3457
-
Views
-
Cite
Cite
Ada S Cheung, Hans A Gray, Anthony G Schache, Rudolf Hoermann, Jarrod Bicknell, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann, Biomechanical Leg Muscle Function During Stair Ambulation in Men Receiving Androgen Deprivation Therapy, The Journals of Gerontology: Series A, Volume 75, Issue 9, September 2020, Pages 1715–1722, https://doi.org/10.1093/gerona/glz169
Close - Share Icon Share
Abstract
The role of testosterone in maintaining functional performance in older men remains uncertain.
We conducted a 12-month prospective, observational case–control study including 34 men newly commencing androgen deprivation therapy for prostate cancer and 29 age-matched prostate cancer controls. Video-based motion capture and ground reaction force data combined with computational musculoskeletal modeling, and data were analyzed with a linear mixed model.
Compared with controls over 12 months, men receiving androgen deprivation therapy had a mean reduction in circulating testosterone from 14.1 nmol/L to 0.4 nmol/L, associated with reductions in peak knee extension torque, mean adjusted difference (MAD) –0.07 Nm/kg (95% confidence interval [CI]: –0.18, 0.04), p = .009, with a corresponding more marked decrease in quadriceps force MAD –0.11 × body weight (BW) [–0.27, 0.06], p = .045 (equating to a 9 kg force reduction for the mean body weight of 85 kg), and decreased maximal contribution of quadriceps to upward propulsion, MAD –0.47 m/s2 [–0.95, 0.02], p = .009. We observed between-group differences in several other parameters, including increased gluteus maximus force in men receiving androgen deprivation therapy, MAD 0.11 × BW [0.02, 0.20], p = .043, which may be compensatory.
Severe testosterone deprivation over 12 months is associated with selective deficits in lower-limb function evident with an important task of daily living.
