Volume 112, Issue 4, April 2025

This review explores the mechanism of FOXL2 in female sex differentiation and maintenance, hormone synthesis, and disease occurrence and depicts the role of FOXL2 as a central factor in female sex development and fertility maintenance.

Mismatch between cell differentiation and mitochondrial maturity prevents transition from minor to major ZGA in mouse embryos.

We describe a molecule acts in the pre-implantation period to attenuate oxidative stress that enhances embryo development to the blastocyst stage and subsequent pregnancy in cattle.

PTEN deficiency induces polarization of M2 macrophages by promoting glycolytic activity in EESCs, which is crucial for deepening the understanding of the pathophysiology of endometriosis and providing new insights for the treatment of endometriosis.

Disruption of motile cilia function in the oviduct affects egg/embryo transport and fertility in mice revealed by genetic and advanced imaging approaches.

Differences in the amino acid composition of the EF-hand domain of mouse and rat PLCZ1s, especially in the charged residues, determine the activities of these enzymes that translate into the distinct Ca²⁺ oscillation patterns of fertilization.

The identified factors and bidirectional communication of local signals originating from the granulosa and thecal layer cells were obtained in different stages of duck follicles by data-independent acquisition.

Granulosa cells undergo acute stress responses within a few days on an obesogenic diet, inhibiting retinol metabolism, and bile acid, fatty acid, and steroid hormone synthesis pathways after long-term exposure, with late oocyte mitochondrial defects.

Two distinct collagen degradation pathways allow for cervical collagen turnover in non-pregnancy, term pregnancy, and inflammation-mediated preterm birth.

Creatine is abundant in maternal and fetal plasma and fetal fluids, and enzymes required for metabolism of creatine are expressed in uteri, placentae, and fetuses of pigs indicating a role for creatine in fetal–placental development.

SHP2 mediates HIF-1 signaling and lactate metabolism within decidual cells by regulating the transcriptional activation of HIF-1α and its downstream genes.

Serum AMH concentrations are associated with subsequent ovarian stimulation outcomes in cheetahs and domestic cats, including progestogen concentrations and in vitro embryonic cleavage in cheetahs and counts of ovulations in both cheetahs and cats.

Deletion of an evolutionarily conserved TAD boundary near spermatogenesis-related genes in mice alters local gene expression and affects sperm production.