Volume 112, Issue 1, January 2025
Reviews
Decoding recurrent pregnancy loss: insights from comparative proteomics studies
This review describes the overall findings from comparative proteomics studies about the pathogenesis of recurrent pregnancy loss in terms of altered pathways, processes, and candidate biomarkers.
In vitro maturation of oocytes: what is already known?
Research Articles
Embryo
Zygotic activin A is dispensable for the mouse preimplantation embryo development and for the derivation and pluripotency of embryonic stem cells
Summary Sentence
The knockout of zygotic activin A affects neither the development of embryos to the blastocyst stage nor the derivation and maintenance of embryonic stem cells; however, it may impair the ability of embryos to implantation.
CTNND1 affects trophoblast proliferation and specification during human embryo implantation
Summary Sentence
Those observations identified the role of cell adhesion-mediated Wnt signaling in human trophoblast stem cell self-renewal, as well as suggest that this signaling pathway controls a transitional state that is crucial for trophoblast lineage specification.
Female Reproductive Tract
Small extracellular vesicles derived from the crosstalk between early embryos and the endometrium potentially mediate corpus luteum function
Summary Sentence: A single Day-7 in vivo or in vitro-produced bovine embryo differentially modifies the endometrial transcriptome and the miRNA content in the released small extracellular vesicles, which can also lead to modifications in the mRNA and miRNA profile of luteal cells.
Roe deer uterine fluid metabolome reveals elevated glycolysis, fatty acid breakdown, and spermidine synthesis upon reactivation from diapause
Summary Sentence
The metabolic changes in the uterine fluid of the European roe deer including triglyceride and diglyceride breakdown, elevated glycolysis, and increased spermidine levels, facilitate reactivation from diapause and/or embryo elongation.
Gamete Biology
Unveiling novel regulatory mechanisms of miR-5195-3p in pelvic organ prolapse pathogenesis
Ovary
Functional characterization of human recessive DIS3 variants in premature ovarian insufficiency
Summary Sentence
DIS3 variant identified in a patient with premature ovarian insufficiency has reduced capacity to rescue Drosophila ovarian Dis3 knockdown compared to wildtype, suggesting the variant is hypomorphic and the RNA exosome is critical for ovarian function.
Pregnancy
The loss of dNK1/2 and EVT1 cells at the maternal–fetal interface is associated with recurrent miscarriage
Delayed endometrial preparation for the induction of luteolysis as a potential factor for improved reproductive performance in Angus beef heifers with high antral follicle counts
Up-regulation of endometrial oxytocin receptor transcription is a prerequisite for the initiation of luteolysis and occurs later in heifers with increased ovarian reserve indicating temporal differences in the initiation of luteolysis.
Taurine is essential for mouse uterine luminal fluid resorption during implantation window via the SCNN1A and AQP8 signaling
Summary Sentence
Taurine plays a crucial role in mouse uterine luminal fluid resorption and embryo implantation by enhancing Scnn1a expression through the RAF1/MEK/ERK signaling pathway and suppressing Aqp8 expression via the AMPK pathway.
Reproductive Technology
Single-cell RNA sequencing reveals common interactions between follicle immune cells and granulosa cells in premature ovarian insufficiency patients
Summary Sentence
Composition of immune cells and granulosa cells of follicular fluid in POI patients, AMA, and normal individuals.
Testis
Loss of CCDC188 causes male infertility with defects in the sperm head–neck connection in mice
Ccdc188 is essential for a tight linkage between the sperm head and neck, and loss of CCDC188 leads to infertility in male mice due to acephalic spermatozoa with motility defects.
Characterization of a novel and testis-specific zinc finger protein during sexual development of Pacific white shrimp Litopenaeus vannamei
Summary Sentence
pTZFP participates in testicular development by regulating spermatogonia proliferation, and its male-biased expression profile provides an appropriate molecular marker for identifying the critical window of gonadal sex differentiation in penaeid shrimp.
Toxicology
Dietary exposure to di(2-ethylhexyl) phthalate for 6 months alters markers of female reproductive aging in mice
Summary Sentence
Exposure to di(2-ethylhexyl) phthalate (DEHP) for 6 months affects markers of female reproductive aging in mice.
