Volume 100, Issue 6, June 2019

TGF-β has a dual effect in tumor progression and can switch the cell fate from apoptosis to proliferation, and possibly plays a similar role in endometrium during the early pregnancy.

Endo-siRNAs function on early embryos in pig.

Comparative examination of ubiquitous promoters in an in vitro ES cell differentiation system and Tg animals provides fundamental insights into suitable promoters for high-level transgene expression in cynomolgus monkeys.

Individual endometrial cells contribute to endometriosis lesion expansion, inflammatory burden, and neovasculature in a model of retrograde menstruation.

The perforatorium is a distinct region of the perinuclear theca of falciform spermatozoa whose assembly during spermiogenesis is temporally and mechanistically linked to the postacrosomal sheath, resulting in many proteins being shared between these regions of the perinuclear theca.

Plasminogen activator, tissue type and its inhibitor serpin family E member 1 cooperatively regulate germinal vesicle breakdown and cumulus expansion of bovine cumulus-oocyte complexes in vitro.

Glucose uptake is mediated by membrane rafts, which results in stimulation of AR induction via AMP-activated protein kinase (AMPK) activation.

Although mating and ovulation were normal, oocyte and embryo quality were reduced; peri-implantation embryonic loss was associated with reduced oocyte and embryo developmental potential in vitro.

Epididymal expression of copper transporting proteins that contribute to the establishment of copper concentrations in luminal fluid in individual regions of epididymis and act in concert to provide copper to CCS-SOD1 complex in spermatozoa.

Our findings represent the first evidence of a direct role for the recombinant human follicle stimulating hormone in inducing chemoresistance to doxorubicin and cyclophosphamide in different human breast cancer cells via hypoxia-inducible factor 1-alpha activation.

Increased hypothalamic NMDAR1 expression correlates to precocious puberty. MiR-664-2 regulates precocious puberty onset. MiR-664-2 targets NMDAR1 and modulates the HPGA activity.

Dopamine production is not impaired in hyperprolactinemic elephants as previously thought and perhaps augmented.

Prenatal exposure to DEHP + high-fat causes synaptic defects and affects folliculogenesis in F1 females.

PGRMC1 and 2 regulates granulosa cell mitosis.

Transcriptomic and proteomic profiling demonstrated that luteal rescue during early pregnancy is mediated by a variety of events, including alteration of immune cell function and matrix remodeling, and that these may be miRNA-regulated.

Matrix metalloproteinases 2 and 9 are elevated in preterm laboring myometrium, promote myometrial contraction, and may contribute to parturition timing.

Dexamethasone induces telomere-dependent p21 mediated non-replicated and non-inflammatory senescence in fetal amnion epithelial cells.

The G protein-coupled receptor signaling protein GIT2 is involved in the genesis of inflammation-induced pro-labor mediators in myometrium and fetal membranes.

Ovine UA hydrogen sulfide production is significantly upregulated via selective upregulation of endothelium and smooth muscle cystathionine β-synthase expression in the follicular phase and pregnancy.

We established a technique for visualizing and tracing live type A spermatogonia (ASGs) of Pacific bluefin tuna using fluorescent dye-conjugated monoclonal antibodies that can recognize the cell surface antigens of ASGs.

Prepubertal testicular cells undergo in vitro morphogenesis and give rise to spherical organoids with testes-specific tissue architecture.

Histone methylation (H3K4me2) is highly conserved from spermatogonia to sperm and is associated with gene expression in spermatogenesis and embryo development.

Non-canonical RNA polyadenylation enzyme FAM46C is specifically expressed in the manchette of spermatids in mouse testes and plays an essential role in spermiogenesis by fastening the sperm head and tail together.