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Masao GOTO, Yuko TAKANO-ISHIKAWA, Hiroshi ONO, Mitsuru YOSHIDA, Kohji YAMAKI, Hiroshi SHINMOTO, Orally Administered Bisphenol A Disturbed Antigen Specific Immunoresponses in the Naïve Condition, Bioscience, Biotechnology, and Biochemistry, Volume 71, Issue 9, 23 September 2007, Pages 2136–2143, https://doi.org/10.1271/bbb.70004
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Abstract
Bisphenol A [2,2-bis(4-hydoxyphenyl)propane; BPA] is an endocrine disrupter widely used in polycarbonate plastics and epoxy resins. We investigated the effects of orally administered BPA on antigen-specific responses of the naïve immune system.
BPA was orally administered to T cell receptor transgenic mice, and the antigen-specific responses of immune cells were investigated. Administered BPA moderately reduced interleukin (IL)-2, 4, and interferon (IFN)-γ secretion and increases in IgA and IgG2a production.
Additionally, it was found that orally administered BPA increased antigen-specific IFN-γ production of T cells and modified whole antigen presenting cells (APCs) to suppress antigen-specific cytokine production from T cells.
These findings suggest that BPA can augment the Th1-type responses of naïve immune systems, though the bioavailability of orally administered BPA was low in our experiments.