Abstract

The aim of the present study was to determine if there is an association of G-protein β3 subunite (GNB3) gene polymorphisms and left ventricular hypertrophy (LVH) in patients with essential hypertension (EH) in St.Petersburg population.

We examined 135 patients (the mean age 48±7yrs) with mild to moderate EH recruited from the general population of the outpatient hypertensive clinic. Left ventricular mass was measured by echocardiography and left ventricular mass index (LVMI) was calculated. The GNB3 C825T genotype was determined by polymerase chain reaction and restriction digestion.

67 patients (0.50) were homozygous for the C allele (CC), 56 were heterozygous (CT) (0.41) and twelve (0.09) were homozygous for T allele (TT). The distribution of genotypes among the patients was in Hardy-Weinberg equilibrium and did not differ significantly when comparing patients with or without LVH. The frequency of T allele was only slightly higher in patients with LVH (0,32) compared to ones without LVH (0.28) and LVMI was similar in patients with CC, CT and TT genotype (120.2±13.4, 120.4±13.6, 122.3±12.4 g/m2, respectively).

In the light of these observations it seems reasonable to conclude that no association of LVH and CNB3 gene variant has been found in the population studied.

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