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Barbara M. Suwelack, Uta Hillebrand, Ulf M. W. Gerhardt, Manuela Kempkes, Karl H. Rahn, Helge Hohage, P-134: Does ACE polymorphism influence blood pressure and S-creatinine under ACE-inhibitor treatment?, American Journal of Hypertension, Volume 14, Issue S1, April 2001, Page 75A, https://doi.org/10.1016/S0895-7061(01)01743-5
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Abstract
Aim&Scope:
We know 3 different genotypes of the ACE gene, DD, ID and II (I=Insertion / D= Deletion). The present study tests the hypothesis that different ACE genotypes may show differences under ACE inhibition.
Material and methods:
In 3 vs. 4 vs. 9 kidney transplant recipients with genotype II, DD and ID the s-creatinine and the arterial blood pressure were estimated before and after 24 months of ACE inhibitor treatment.
Results:
The tables show that, unexpectedly, the arterial blood pressure is significantly reduced only in the II group. On the other hand, s-creatinine decreased significantly only in the DD group.
(see table)
. | CREA 0 . | Crea 24 . | Δ Crea . |
---|---|---|---|
II | 1,38 +/- 0,15 | 1,39 +/- 0,28 | -0,01 +/- 0,17 |
DD | 1,70 +/- 0,11* | 1,48 +/- 0,16 | 0,23 +/- 0,08* |
ID | 1,33 +/- 0,15 | 1,42 +/- 0,16 | -0,09 +/- 0,16 |
. | CREA 0 . | Crea 24 . | Δ Crea . |
---|---|---|---|
II | 1,38 +/- 0,15 | 1,39 +/- 0,28 | -0,01 +/- 0,17 |
DD | 1,70 +/- 0,11* | 1,48 +/- 0,16 | 0,23 +/- 0,08* |
ID | 1,33 +/- 0,15 | 1,42 +/- 0,16 | -0,09 +/- 0,16 |
. | CREA 0 . | Crea 24 . | Δ Crea . |
---|---|---|---|
II | 1,38 +/- 0,15 | 1,39 +/- 0,28 | -0,01 +/- 0,17 |
DD | 1,70 +/- 0,11* | 1,48 +/- 0,16 | 0,23 +/- 0,08* |
ID | 1,33 +/- 0,15 | 1,42 +/- 0,16 | -0,09 +/- 0,16 |
. | CREA 0 . | Crea 24 . | Δ Crea . |
---|---|---|---|
II | 1,38 +/- 0,15 | 1,39 +/- 0,28 | -0,01 +/- 0,17 |
DD | 1,70 +/- 0,11* | 1,48 +/- 0,16 | 0,23 +/- 0,08* |
ID | 1,33 +/- 0,15 | 1,42 +/- 0,16 | -0,09 +/- 0,16 |
In Group II, the MAD decreased from 114,78+/-1,44 mmHg to 93,00+/-3,34 mmHg (ΔMAP 21,78+/-3,76 mmHg; p<0.05). However no significant MAP reduction was found in DD (ΔMAP 0,67+/-4,89 mmHg) or ID (Δ MAP 2,26+/-3,42 mmHg).
Conclusion:
These preliminary results show a strong blood pressure effect in the II ACE-genotype patients, whereas the reduction of s-creatinine is higher in the DD group. However, the underlying mechanisms have not been clarified yet.