Abstract

Aim&Scope:

We know 3 different genotypes of the ACE gene, DD, ID and II (I=Insertion / D= Deletion). The present study tests the hypothesis that different ACE genotypes may show differences under ACE inhibition.

Material and methods:

In 3 vs. 4 vs. 9 kidney transplant recipients with genotype II, DD and ID the s-creatinine and the arterial blood pressure were estimated before and after 24 months of ACE inhibitor treatment.

Results:

The tables show that, unexpectedly, the arterial blood pressure is significantly reduced only in the II group. On the other hand, s-creatinine decreased significantly only in the DD group.

(see table)

CREA 0Crea 24Δ Crea
II1,38 +/- 0,151,39 +/- 0,28-0,01 +/- 0,17
DD1,70 +/- 0,11*1,48 +/- 0,160,23 +/- 0,08*
ID1,33 +/- 0,151,42 +/- 0,16-0,09 +/- 0,16
CREA 0Crea 24Δ Crea
II1,38 +/- 0,151,39 +/- 0,28-0,01 +/- 0,17
DD1,70 +/- 0,11*1,48 +/- 0,160,23 +/- 0,08*
ID1,33 +/- 0,151,42 +/- 0,16-0,09 +/- 0,16
CREA 0Crea 24Δ Crea
II1,38 +/- 0,151,39 +/- 0,28-0,01 +/- 0,17
DD1,70 +/- 0,11*1,48 +/- 0,160,23 +/- 0,08*
ID1,33 +/- 0,151,42 +/- 0,16-0,09 +/- 0,16
CREA 0Crea 24Δ Crea
II1,38 +/- 0,151,39 +/- 0,28-0,01 +/- 0,17
DD1,70 +/- 0,11*1,48 +/- 0,160,23 +/- 0,08*
ID1,33 +/- 0,151,42 +/- 0,16-0,09 +/- 0,16

In Group II, the MAD decreased from 114,78+/-1,44 mmHg to 93,00+/-3,34 mmHg (ΔMAP 21,78+/-3,76 mmHg; p<0.05). However no significant MAP reduction was found in DD (ΔMAP 0,67+/-4,89 mmHg) or ID (Δ MAP 2,26+/-3,42 mmHg).

Conclusion:

These preliminary results show a strong blood pressure effect in the II ACE-genotype patients, whereas the reduction of s-creatinine is higher in the DD group. However, the underlying mechanisms have not been clarified yet.

This content is only available as a PDF.
You do not currently have access to this article.