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Henrik M. Reims, Aud Høieggen, Eigil Fossum, Morten Rostrup, Ivar Eide, Sverre E. Kjeldsen, P-641: Glucose disposal rates calculated from 60-90 min isoglycemic, hyperinsulinemic glucose clamp correlate with cardiovascular risk factors in borderline hypertensive, young men, American Journal of Hypertension, Volume 14, Issue S1, April 2001, Page 244A, https://doi.org/10.1016/S0895-7061(01)01971-9
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Abstract
1. We aimed to analyse the 120 min hyperinsulinemic glucose clamp regarding the time aspect of relationships between glucose disposal rate (GDR) and cardiovascular risk factors.
2. The isoglycemic, hyperinsulinemic glucose clamp was performed on 19 borderline hypertensive (BP≥ 140/90 mmHg), but otherwise healthy, young men. GDR was calculated from 20 min periods at different time points and related to baseline risk factors and responses to a mental stress test.
3. GDR at 60, 90 and 120 min correlated with systolic BP, heart rate (HR), body mass index (BMI) and lipid levels as well as to HR, BP and plasma catecholamine levels during mental stress. Though not statistically significant at all time points, the relationships showed consistency from 40-50 min onwards. (See Table)
. | . | GDR 60 min . | GDR 90 min . | GDR 120 min . | |||
---|---|---|---|---|---|---|---|
. | . | r . | p . | r . | p . | r . | p . |
Baseline | |||||||
Hgb | -0.58 | 0.012 | -0.42 | 0.080 | -0.33 | 0.180 | |
BMI | -0.47 | 0.040 | -0.42 | 0.076 | -0.46 | 0.049 | |
Chol | -0.35 | 0.138 | -0.37 | 0.125 | -0.48 | 0.038 | |
HDL | 0.59 | 0.007 | 0.50 | 0.029 | 0.53 | 0.020 | |
TG | -0.41 | 0.081 | -0.39 | 0.103 | -0.46 | 0.046 | |
SBP | -0.49 | 0.033 | -0.36 | 0.134 | -0.30 | 0.122 | |
HR | -0.42 | 0.073 | -0.44 | 0.062 | -0.39 | 0.095 | |
Glucose Clamp and Mental Stress | |||||||
SBP-120 | -0.55 | 0.015 | -0.43 | 0.065 | -0.44 | 0.062 | |
SBP-A | -0.58 | 0.010 | -0.50 | 0.028 | -0.41 | 0.080 | |
HR-A | -0.40 | 0.090 | -0.55 | 0.016 | -0.55 | 0.015 | |
HR-MST | -0.65 | 0.003 | -0.64 | 0.003 | -0.58 | 0.010 | |
Epi-D | -0.46 | 0.062 | -0.49 | 0.044 | -0.52 | 0.034 | |
Epi-A | -0.55 | 0.019 | -0.58 | 0.012 | -0.56 | 0.010 | |
NE-A | -0.52 | 0.027 | -0.49 | 0.038 | -0.48 | 0.042 |
. | . | GDR 60 min . | GDR 90 min . | GDR 120 min . | |||
---|---|---|---|---|---|---|---|
. | . | r . | p . | r . | p . | r . | p . |
Baseline | |||||||
Hgb | -0.58 | 0.012 | -0.42 | 0.080 | -0.33 | 0.180 | |
BMI | -0.47 | 0.040 | -0.42 | 0.076 | -0.46 | 0.049 | |
Chol | -0.35 | 0.138 | -0.37 | 0.125 | -0.48 | 0.038 | |
HDL | 0.59 | 0.007 | 0.50 | 0.029 | 0.53 | 0.020 | |
TG | -0.41 | 0.081 | -0.39 | 0.103 | -0.46 | 0.046 | |
SBP | -0.49 | 0.033 | -0.36 | 0.134 | -0.30 | 0.122 | |
HR | -0.42 | 0.073 | -0.44 | 0.062 | -0.39 | 0.095 | |
Glucose Clamp and Mental Stress | |||||||
SBP-120 | -0.55 | 0.015 | -0.43 | 0.065 | -0.44 | 0.062 | |
SBP-A | -0.58 | 0.010 | -0.50 | 0.028 | -0.41 | 0.080 | |
HR-A | -0.40 | 0.090 | -0.55 | 0.016 | -0.55 | 0.015 | |
HR-MST | -0.65 | 0.003 | -0.64 | 0.003 | -0.58 | 0.010 | |
Epi-D | -0.46 | 0.062 | -0.49 | 0.044 | -0.52 | 0.034 | |
Epi-A | -0.55 | 0.019 | -0.58 | 0.012 | -0.56 | 0.010 | |
NE-A | -0.52 | 0.027 | -0.49 | 0.038 | -0.48 | 0.042 |
. | . | GDR 60 min . | GDR 90 min . | GDR 120 min . | |||
---|---|---|---|---|---|---|---|
. | . | r . | p . | r . | p . | r . | p . |
Baseline | |||||||
Hgb | -0.58 | 0.012 | -0.42 | 0.080 | -0.33 | 0.180 | |
BMI | -0.47 | 0.040 | -0.42 | 0.076 | -0.46 | 0.049 | |
Chol | -0.35 | 0.138 | -0.37 | 0.125 | -0.48 | 0.038 | |
HDL | 0.59 | 0.007 | 0.50 | 0.029 | 0.53 | 0.020 | |
TG | -0.41 | 0.081 | -0.39 | 0.103 | -0.46 | 0.046 | |
SBP | -0.49 | 0.033 | -0.36 | 0.134 | -0.30 | 0.122 | |
HR | -0.42 | 0.073 | -0.44 | 0.062 | -0.39 | 0.095 | |
Glucose Clamp and Mental Stress | |||||||
SBP-120 | -0.55 | 0.015 | -0.43 | 0.065 | -0.44 | 0.062 | |
SBP-A | -0.58 | 0.010 | -0.50 | 0.028 | -0.41 | 0.080 | |
HR-A | -0.40 | 0.090 | -0.55 | 0.016 | -0.55 | 0.015 | |
HR-MST | -0.65 | 0.003 | -0.64 | 0.003 | -0.58 | 0.010 | |
Epi-D | -0.46 | 0.062 | -0.49 | 0.044 | -0.52 | 0.034 | |
Epi-A | -0.55 | 0.019 | -0.58 | 0.012 | -0.56 | 0.010 | |
NE-A | -0.52 | 0.027 | -0.49 | 0.038 | -0.48 | 0.042 |
. | . | GDR 60 min . | GDR 90 min . | GDR 120 min . | |||
---|---|---|---|---|---|---|---|
. | . | r . | p . | r . | p . | r . | p . |
Baseline | |||||||
Hgb | -0.58 | 0.012 | -0.42 | 0.080 | -0.33 | 0.180 | |
BMI | -0.47 | 0.040 | -0.42 | 0.076 | -0.46 | 0.049 | |
Chol | -0.35 | 0.138 | -0.37 | 0.125 | -0.48 | 0.038 | |
HDL | 0.59 | 0.007 | 0.50 | 0.029 | 0.53 | 0.020 | |
TG | -0.41 | 0.081 | -0.39 | 0.103 | -0.46 | 0.046 | |
SBP | -0.49 | 0.033 | -0.36 | 0.134 | -0.30 | 0.122 | |
HR | -0.42 | 0.073 | -0.44 | 0.062 | -0.39 | 0.095 | |
Glucose Clamp and Mental Stress | |||||||
SBP-120 | -0.55 | 0.015 | -0.43 | 0.065 | -0.44 | 0.062 | |
SBP-A | -0.58 | 0.010 | -0.50 | 0.028 | -0.41 | 0.080 | |
HR-A | -0.40 | 0.090 | -0.55 | 0.016 | -0.55 | 0.015 | |
HR-MST | -0.65 | 0.003 | -0.64 | 0.003 | -0.58 | 0.010 | |
Epi-D | -0.46 | 0.062 | -0.49 | 0.044 | -0.52 | 0.034 | |
Epi-A | -0.55 | 0.019 | -0.58 | 0.012 | -0.56 | 0.010 | |
NE-A | -0.52 | 0.027 | -0.49 | 0.038 | -0.48 | 0.042 |
GDR, glucose disposal rate; SBP-120, SBP at 120 min of clamp; HR-MST, HR during mental stress test (MST); Epi, epinephrine; NE, norepinephrine; -A; after announcement of MST; -D, during announcement of MST.
4. We suggest that 60-90 min glucose clamps may provide information about relationships between insulin sensitivity and cardiovascular risk factors in borderline hypertensive, young Caucasian men.
- norepinephrine
- epinephrine
- hypertension
- body mass index procedure
- heart disease risk factors
- heart rate
- systolic blood pressure
- psychological stress
- glucose
- hemoglobin
- high density lipoproteins
- plasma
- european continental ancestry group
- lipids measurement
- catecholamines measurement
- insulin sensitivity