-
Views
-
Cite
Cite
Linwei Wang, Scarlett Lin Gomez, Yutaka Yasui, THE AUTHORS REPLY, American Journal of Epidemiology, Volume 188, Issue 6, June 2019, Pages 1192–1193, https://doi.org/10.1093/aje/kwz076
Close - Share Icon Share
Extract
We thank Spector et al. (1) for their insightful comments on our article (2). We focused on the results and discussion around the relationship between socioeconomic position (SEP) and incidence of childhood acute lymphoblastic leukemia (ALL) and the way it differed by race/ethnicity. The letter presented crude (i.e., not age-adjusted) incidence rate ratios comparing racial/ethnic groups within strata of SEP. Based on the racial/ethnic differences according to SEP strata, the authors concluded that ancestry plays an important role in ALL risk and therefore that conducting admixture mapping among highly admixed populations could identify risk loci.
First, we would like to supplement the letter by presenting the adjusted incidence rate ratios of ALL comparing racial/ethnic groups stratified by SEP, adjusting for sex, age, and year of diagnosis (Table 1). The adjusted incidence rate ratios were comparable to the crude incidence rate ratios. Moreover, the trend tests suggested a narrowing gap between non-Hispanic whites and other racial/ethnic groups (statistically significant for Hispanics; marginally significant for non-Hispanic blacks and Asians/Pacific Islanders) in the incidence of childhood ALL, with increasing SEP.
...
