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Clinical Chemistry
Clinical Chemistry is a high-impact peer-reviewed publication, ranked as the most cited journal in the fields of clinical chemistry, clinical or anatomic pathology, analytical chemistry, transfusion medicine, and clinical microbiology.
Journal

The Journal of Applied Laboratory Medicine
The Journal of Applied Laboratory Medicine is an online-only, peer-reviewed
publication showcasing clinically relevant laboratory topics in applied and
translational research.
Journal Article
Clinical and Molecular Characteristics of a Patient with 11-Beta-Hydroxylase Deficiency
Malgorzata Monika Brzozowska and others
The Journal of Applied Laboratory Medicine, jfaf038, https://doi.org/10.1093/jalm/jfaf038
Published: 09 May 2025
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Medians with 90% confidence intervals established in early pregnancy for so...
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The Journal of Applied Laboratory Medicine
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Reference Intervals for Placental Biomarkers in Early Pregnancy
Published: 09 May 2025
Fig. 1.
Medians with 90% confidence intervals established in early pregnancy for soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), β-human chorionic gonadotropin (β-hCG), and pregnancy-associated plasma protein A (PAPP-A) and stratified by weeks of pregnancy.
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Means with 95% confidence intervals (CIs) for the association between mater...
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The Journal of Applied Laboratory Medicine
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Reference Intervals for Placental Biomarkers in Early Pregnancy
Published: 09 May 2025
Fig. 2.
Means with 95% confidence intervals (CIs) for the association between maternal age and soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), β-human chorionic gonadotropin (β-hCG), and pregnancy-associated plasma protein A (PAPP-A) in early pregnancy using linear regression. O
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Means with 95% confidence intervals (CIs) for the association between mater...
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The Journal of Applied Laboratory Medicine
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Reference Intervals for Placental Biomarkers in Early Pregnancy
Published: 09 May 2025
Fig. 3.
Means with 95% confidence intervals (CIs) for the association between maternal pre-pregnancy body mass index (BMI) and soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), β-human chorionic gonadotropin (β-hCG), and pregnancy-associated plasma protein A (PAPP-A) in early preg
Journal Article
Commentary on Clinical and Molecular Characteristics of Patient with 11-Beta-Hydroxylase Deficiency
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Sharon Markham Geaghan
The Journal of Applied Laboratory Medicine, jfaf049, https://doi.org/10.1093/jalm/jfaf049
Published: 09 May 2025
Journal Article
Reference Intervals for Placental Biomarkers in Early Pregnancy
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Maja Hjelm Lundgaard and others
The Journal of Applied Laboratory Medicine, jfaf064, https://doi.org/10.1093/jalm/jfaf064
Published: 09 May 2025
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Enrollment summary. aIn total, 640 aliquots were measured, inclu...
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The Journal of Applied Laboratory Medicine
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Reference Range Determination for the sFlt-1/PlGF Ratio in a Diverse Cohort of Pregnant Women in the United States
Published: 07 May 2025
Fig. 1.
Enrollment summary. a In total, 640 aliquots were measured, including 561 blood samples evaluable for analysis and 79 blood samples from enrolled women who were excluded after enrollment and at postpartum follow-up. b Details on other reasons for exclusion postenrollment are provided in Supplemen
Journal Article
Reference Range Determination for the sFlt-1/PlGF Ratio in a Diverse Cohort of Pregnant Women in the United States
Antonio F Saad and others
The Journal of Applied Laboratory Medicine, jfaf063, https://doi.org/10.1093/jalm/jfaf063
Published: 07 May 2025
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Genomic landscape of cfDNA alterations. (A), Oncoplot of genomic alteration...
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Clinical Chemistry
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Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA for Identification of Targetable and Resistance Alterations in Advanced Solid Tumors
Published: 05 May 2025
Fig. 3.
Genomic landscape of cfDNA alterations. (A), Oncoplot of genomic alterations detected from plasma cfDNA. The data for each individual patient is displayed as a single vertical column, with samples grouped based on their cancer type. Colors indicate the highest OncoKB level alteration detected from e
Journal Article
Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA for Identification of Targetable and Resistance Alterations in Advanced Solid Tumors
Hiu Ting Chan and others
Clinical Chemistry, hvaf045, https://doi.org/10.1093/clinchem/hvaf045
Published: 05 May 2025
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Overview of the tumor genomic profiling analysis. Patients with advanced so...
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Clinical Chemistry
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Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA for Identification of Targetable and Resistance Alterations in Advanced Solid Tumors
Published: 05 May 2025
Fig. 1.
Overview of the tumor genomic profiling analysis. Patients with advanced solid tumors and eligible for tissue tumor profiling were recruited for the study ( n = 298). The most recently retrieved FFPE tissue samples were submitted to Foundation Medicine for testing using the FoundationOne CDx compre
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Concordance of alterations between cfDNA and tissue. (A), Stacked bar graph...
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Clinical Chemistry
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Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA for Identification of Targetable and Resistance Alterations in Advanced Solid Tumors
Published: 05 May 2025
Fig. 4.
Concordance of alterations between cfDNA and tissue. (A), Stacked bar graph showing concordance of 282 patients that had both tumor and cfDNA data available. Concordant patients (71.6%) are represented by the combined bottom and second segments of the bar, encompassing cases where no mutatioins were
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Correlation of clinical factors and mut-ctDNA detection. (A), Concordance r...
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Clinical Chemistry
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Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA for Identification of Targetable and Resistance Alterations in Advanced Solid Tumors
Published: 05 May 2025
Fig. 5.
Correlation of clinical factors and mut-ctDNA detection. (A), Concordance rate of cfDNA genotyping relative to tissue genomic profiling by cancer type at patient level; (B), Comparison of lesion size by concordant detection of mutations from plasma and undetected from plasma or detected at VAF <0
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Clinical experience with the Oncomine Precision Assay together with the Gen...
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Clinical Chemistry
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Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA for Identification of Targetable and Resistance Alterations in Advanced Solid Tumors
Published: 05 May 2025
Fig. 2.
Clinical experience with the Oncomine Precision Assay together with the Genexus System. (A), Sequencing success rates for tissue and cfDNA genomic profiling ( n = 298, P = 1.96 × 10 −2 ). The P value was obtained from two-by-two Fisher exact test; (B), Distribution of the age of tissues that we
Journal Article
Quality Control Measurements Yield Similar Variation Below and Above Limit of Quantification for High-Sensitivity Cardiac Troponin I Assays
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Peter A Kavsak and others
Clinical Chemistry, hvaf057, https://doi.org/10.1093/clinchem/hvaf057
Published: 02 May 2025
Journal Article
Red Blood Cell-Bound Cell-Free DNA Is an Insensitive Marker for Diagnosis of Bacterial Infections
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Kanagavel Murugesan and others
Clinical Chemistry, hvaf053, https://doi.org/10.1093/clinchem/hvaf053
Published: 02 May 2025
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Within-subject BV of erythrocyte zinc protoporphyrin in participants with E...
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Clinical Chemistry
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Biological Variation of Erythrocyte Total, Metal-Free, and Zinc Protoporphyrin IX in Patients with Erythropoietic Protoporphyria and Healthy Subjects: Implications for Clinical Interpretation and Monitoring
Published: 02 May 2025
Fig. 4.
Within-subject BV of erythrocyte zinc protoporphyrin in participants with EPP and in healthy subjects. The figure displays median estimated personal within-subject BV (represented by squares for females and triangles for males) accompanied by their respective 95% credible intervals (depicted by hori
Journal Article
Commentary on M Protein Interference in Renal Function Assays: A Quest for True Kidney Function
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Jayson V Pagaduan
The Journal of Applied Laboratory Medicine, jfaf061, https://doi.org/10.1093/jalm/jfaf061
Published: 02 May 2025