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Clinical Chemistry is a high-impact peer-reviewed publication, ranked as the most cited journal in the fields of clinical chemistry, clinical or anatomic pathology, analytical chemistry, transfusion medicine, and clinical microbiology.
Journal
Issue cover
The Journal of Applied Laboratory Medicine is an online-only, peer-reviewed publication showcasing clinically relevant laboratory topics in applied and translational research.
Journal Article
Malgorzata Monika Brzozowska and others
The Journal of Applied Laboratory Medicine, jfaf038, https://doi.org/10.1093/jalm/jfaf038
Published: 09 May 2025
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Published: 09 May 2025
Fig. 1. Medians with 90% confidence intervals established in early pregnancy for soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), β-human chorionic gonadotropin (β-hCG), and pregnancy-associated plasma protein A (PAPP-A) and stratified by weeks of pregnancy.
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Published: 09 May 2025
Fig. 2. Means with 95% confidence intervals (CIs) for the association between maternal age and soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), β-human chorionic gonadotropin (β-hCG), and pregnancy-associated plasma protein A (PAPP-A) in early pregnancy using linear regression. O
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Published: 09 May 2025
Fig. 3. Means with 95% confidence intervals (CIs) for the association between maternal pre-pregnancy body mass index (BMI) and soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), β-human chorionic gonadotropin (β-hCG), and pregnancy-associated plasma protein A (PAPP-A) in early preg
Journal Article
Sharon Markham Geaghan
The Journal of Applied Laboratory Medicine, jfaf049, https://doi.org/10.1093/jalm/jfaf049
Published: 09 May 2025
Journal Article
Maja Hjelm Lundgaard and others
The Journal of Applied Laboratory Medicine, jfaf064, https://doi.org/10.1093/jalm/jfaf064
Published: 09 May 2025
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Published: 07 May 2025
Fig. 1. Enrollment summary. a In total, 640 aliquots were measured, including 561 blood samples evaluable for analysis and 79 blood samples from enrolled women who were excluded after enrollment and at postpartum follow-up. b Details on other reasons for exclusion postenrollment are provided in Supplemen
Journal Article
Antonio F Saad and others
The Journal of Applied Laboratory Medicine, jfaf063, https://doi.org/10.1093/jalm/jfaf063
Published: 07 May 2025
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Published: 05 May 2025
Fig. 3. Genomic landscape of cfDNA alterations. (A), Oncoplot of genomic alterations detected from plasma cfDNA. The data for each individual patient is displayed as a single vertical column, with samples grouped based on their cancer type. Colors indicate the highest OncoKB level alteration detected from e
Journal Article
Hiu Ting Chan and others
Clinical Chemistry, hvaf045, https://doi.org/10.1093/clinchem/hvaf045
Published: 05 May 2025
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Published: 05 May 2025
Fig. 1. Overview of the tumor genomic profiling analysis. Patients with advanced solid tumors and eligible for tissue tumor profiling were recruited for the study ( n = 298). The most recently retrieved FFPE tissue samples were submitted to Foundation Medicine for testing using the FoundationOne CDx compre
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Published: 05 May 2025
Fig. 4. Concordance of alterations between cfDNA and tissue. (A), Stacked bar graph showing concordance of 282 patients that had both tumor and cfDNA data available. Concordant patients (71.6%) are represented by the combined bottom and second segments of the bar, encompassing cases where no mutatioins were
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Published: 05 May 2025
Fig. 5. Correlation of clinical factors and mut-ctDNA detection. (A), Concordance rate of cfDNA genotyping relative to tissue genomic profiling by cancer type at patient level; (B), Comparison of lesion size by concordant detection of mutations from plasma and undetected from plasma or detected at VAF <0
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Published: 05 May 2025
Fig. 2. Clinical experience with the Oncomine Precision Assay together with the Genexus System. (A), Sequencing success rates for tissue and cfDNA genomic profiling ( n = 298, P = 1.96 × 10 −2 ). The P value was obtained from two-by-two Fisher exact test; (B), Distribution of the age of tissues that we
Journal Article
Peter A Kavsak and others
Clinical Chemistry, hvaf057, https://doi.org/10.1093/clinchem/hvaf057
Published: 02 May 2025
Journal Article
Kanagavel Murugesan and others
Clinical Chemistry, hvaf053, https://doi.org/10.1093/clinchem/hvaf053
Published: 02 May 2025
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Published: 02 May 2025
Fig. 4. Within-subject BV of erythrocyte zinc protoporphyrin in participants with EPP and in healthy subjects. The figure displays median estimated personal within-subject BV (represented by squares for females and triangles for males) accompanied by their respective 95% credible intervals (depicted by hori
Journal Article
Jayson V Pagaduan
The Journal of Applied Laboratory Medicine, jfaf061, https://doi.org/10.1093/jalm/jfaf061
Published: 02 May 2025