Time course of heart rate and mean arterial blood pressure (INV MAP) and BIS for the control (A, B and C) and intervention (D, E and F) groups. Red lines denote the pre-adjustment phase and blue lines the post-adjustment phase. Vertical grey lines indicate the moment of PK model adjustment (intervention group). Panels G, H and I shows the difference between the mean values (and confidence intervals) between groups. Beats min⁻¹, beat per min; INV MAP, Invasive Mean Arterial Pressure in mm Hg (obtained from an arterial line); Abs. Mn. Diff. Heart Rate/INV MAP/Bispectral Index, Absolute Mean different Heart Rate/Invasive Mean Arterial Pressure/Bispectral Index.