Associations between hepatic DNL and plasma metabolites in women (○) (n = 11) and men (●) (n = 11).

A, The relationship between the contribution (micromoles per liter) of newly synthesized palmitate (DNL) in plasma VLDL-TG (as an AUC) and plasma VLDL-TG concentrations (as an AUC). B, The ratio of plasma C4 to cholesterol (a marker of bile acid synthesis) and the fasting contribution (micromoles per liter) of DNL in plasma VLDL-TG. C, The association between the contribution of DNL in plasma VLDL-TG (as an AUC) and plasma [¹³C]3OHB concentrations (as an AUC).