Proposed algorithm for antithrombotic management of patients with hypertension and non-valvular atrial fibrillation. ASA, Acetylsalicylic acid; NSAID, Non-steroidal anti-inflammatory drug; OAC, Oral anticoagulant; VKA, Vitamin K antagonist; NOAC, Non-vitamin K oral anticoagulant. SAMe-TT₂R₂, sex female, age, 60 years, medical history (more than two comorbidities), treatment (interacting drugs, e.g. amiodarone for rhythm control), tobacco use (doubled), race (doubled); TTR, time in therapeutic range.