Model for regulation of RIG-I and MDA5 by LGP2. Model for LGP2 interaction with dsRNA and proposed regulation of RIG-I- and MDA5-dependent signaling. Stoichiometry and interaction sites are simplified and aspects of the model are speculative. dsRNA binding by both RD and DExH box domains could compete with dsRNA-dependent activation of the RIG-I DExH box domain. A fully functional LGP2 might together with MDA5 sense dsRNA and augment MDA5-dependent signaling.