GRAVY score distributions of predicted cytoplasmic soluble proteins of halophilic protists, marine protists, and Halobacteria. On top, distributions of halophilic protists are significantly shifted toward hydrophilic values compared with homologous proteins from marine protists (Mann–Whitney U test, P < 0.0001). On the bottom, distributions of Haloc. seosinensis and P. kirbyi are slightly shifted toward hydrophilic values compared with the ones of Halobacteria (Whitney, P < 0.02), whereas the distribution for marine protists is significantly shifted toward more hydrophobic values compared with the distribution for Halobacteria (Mann–Whitney U test, P < 0.0001).