Glycolysis is upregulated in angiogenic compared with invasive tumors. (A) MRS of invasive and angiogenic tumors. * P < .005; Lac=Lactate; mI=myo Inositol; Cr=creatine; Ch=choline; NAA+NAAG=; Glu+Gln=glutamine and glutamate; Tau=taurine; NAA+NAAG=N-acetylaspartate + N-acetyl-aspartylglutamate (B) Metabolic mapping of LDH activity in angiogenic compared with invasive tumors. Asterisk indicates necrotic area. (C) Quantification of metabolic mapping. (D) Lactate levels of invasive (P8) and angiogenic (P8-EGFRDN) human GBM cells in 48h and 120h of normoxia and hypoxia. *P < .05; ***P < .001.