Skeletal phenotype in female mice. Micro-CT analysis is shown of vertebral (a) trabecular bone volume over total volume (BV/TV), (b) trabecular thickness (Tb.Th.), (c) trabecular number (Tb.No.), and (d) trabecular separation (Tb.Sp.) in WT and HSD2^OB-tg females at endpoint, followed by tibial (e) trabecular bone volume (BV/TV), (f) trabecular thickness (Tb.Th.), (g) trabecular number (Tb.No.), and (h) trabecular separation (Tb.Sp.). Micro-CT analysis is shown of tibial (i) total periosteal envelope area (Tt.Ar.), (j) cortical area (Ct.Ar.), (k) cortical area fraction (Ct.Ar./Tt.Ar.), and (l) cortical thickness (Ct.Th.) (n = 8 per group). Data are presented as mean ± SD and were analyzed by two-way ANOVA followed by a Holm–Sidak post hoc test. *P < 0.05, **P < 0.01 vs genotype-matched control.