Comparison of DU011 treatment and mutation of mprA in a murine disseminated Escherichia coli infection model. A, Female mice (n = 10 in 2 separate experiments) with and without DU011 pretreatment were infected with wild-type or mprA mutant E. coli UTI89 at a dose previously shown to be lethal for the wild-type E. coli infection. B and C, The number of colony-forming units (CFU) per gram of tissue from the liver (left) and spleen (right) at the time mice were euthanized owing to reaching a moribund state or the end of the experiment. Horizontal lines indicate median values. *P = .01 and **P = .007, by the Mann–Whitney U test. Abbreviation: PBS, phosphate-buffered saline.