Infant rotavirus vaccine coverage and weekly rate (per 1 000 000) of laboratory-confirmed rotavirus infections reported (A) and all-cause acute gastroenteritis (AGE)–associated hospital admissions (B) in England and Wales, July 2000 through June 2015. Dashed black lines represent the start of a national universal rotavirus immunization program with Rotarix (1 July 2013). Coverage assessment was for a full vaccine course (2 doses) by 25 weeks of age.