HuR has a preference for the binding of the 3′-UTR of RRM-type RBPs. ( A ) shows the enrichment of HuR 3′-UTR binding sites for several RNA-binding domains with respect to the most frequent human protein domains and to RBPs as a whole. Data are extracted by the PAR-CLIP experiment published in ( 49 ). ( B ) shows a Venn diagram indicating the overlap between our HuR RRM-type mRNA targets and the experimentally identified HuR PAR-CLIP RRM-type mRNA targets. ( C ) displays HuR 3′-UTR RRM-type mRNA targets, highlighted in different colours and shapes according to their belonging to our set of 23 mRNAs, to mRNAs we validated by RIP-qPCR and their intersection with the RRM-type mRNA targets from the PAR-CLIP data set.