Percentage of participants assigned to receive 9 months of daily self-administered isoniazid (maximum dose, 300 mg) (9H-SAT) who did not complete latent tuberculosis infection treatment (LTBI) attributed to an adverse event (AE) and attributed to reasons other than an AE, by doses taken (n = 3002). This figure shows how the combined proportion of participants who did not complete LTBI treatment attributed to an AE plus the proportion of those who did not complete treatment for reasons other than an AE in the 9H-SAT regimen decreased after the first 30-dose interval and remained constant thereafter. 9H-SAT: ≥240 doses in >52 weeks (60 [2.0%]). Pearson correlation coefficient in a linear regression model = −0.68; P = .03; r2 = 0.46. Abbreviations: NCT-AE, non-completion of LTBI treatment attributed to an adverse event; NCT-O, non-completion of LTBI treatment attributed to reasons other than an adverse event.
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