The strength of diversifying selection. Estimated as p_N/p_S, for P. falciparum proteins with (solid bars) or without predicted immune epitopes (shaded bars) expressed in sexual (male, female) and asexual blood stage malaria parasites. (A) Percentage of proteins containing immune epitopes identified from the Immune Epitope Database and Analysis Resource. Genes were classified according to their exclusive detection in P. berghei proteomes of Males, Females, Asexual Stages or All Stages (see Fig. 1). The strength of diversifying selection on P. falciparum predicted non-membrane (B) and membrane (C) proteins.