Difference in hsCRP concentrations in LDA vs placebo groups during pregnancy. Symbols indicate geometric means of log-transformed hsCRP at baseline (prerandomization) and throughout pregnancy. Squares indicate the lower hsCRP tertile (closed, LDA; open, placebo), triangles indicate the middle hsCRP tertile (closed, LDA; open, placebo), and diamonds indicate the higher hsCRP tertile (closed, LDA; open, placebo). *Notation of significance indicates treatment group (LDA vs placebo) difference across pregnancy (excluding baseline) from generalized estimating equations models within each hsCRP tertile (assigned at baseline).