Glucose homeostasis in bGH and GHR^−/− mice. (A) GTTs, (B) ITTs, and (C) PTTs were performed in bGH mice (white circles) and WT control mice (black circles) (n = 10 per group). Similarly, (D) GTTs, (E) ITTs, and (F) PTTs were performed in GHR^−/− mice (white circles) and WT control mice (black circles) (n = 8 per group). Mice received an IP injection of glucose at 1 g/kg body weight, insulin at 0.75 U/kg body weight, or pyruvate at 1.5 g/kg body weight, respectively. Blood glucose levels are reported as percentage change in glucose from baseline (100%). Relative AUC was calculated for each test in (G) bGH and (H) GHR^−/− mice. Values are expressed as mean ± standard error of the mean.