DHEA-treated mice display disrupted estrous cycles and hormonal levels. (a–d) Representative estrous cycles (n = 4 of each groups) of mice exposed to control, Hcy, DHEA, or Hcy + DHEA for 20 days. The serum levels of (e) testosterone, (f) estrogen, and (g) lipids of mice (n = 10) exposed to control, Hcy, DHEA, or Hcy + DHEA for 20 days. *P < 0.05, one-way analysis of variance, with Tukey’s post hoc test. Ctl, control; HDL, high-density lipoprotein; LDL, low-density lipoprotein; TCHO, total cholesterol; TG, triglyceride.