Hcy exacerbates the metabolic disorders induced by DHEA in mice. (a) Fasting blood glucose and (b) insulin levels of mice exposed to control, Hcy, DHEA, or Hcy + DHEA (n = 5 of each group) for 20 days of treatment. (c) GTT, (d) GTT AUC, (e) ITT, (f) ITT AUC, and (g) HOMA-IR (n = 10) results of four groups. *P < 0.05, one-way analysis of variance, with Tukey’s post hoc test. (c, e) *P < 0.05 vs controls, ^#P < 0.05 vs DHEA. Ctl, control; HOMA-IR, homeostatice model assessment of IR.