Schematic illustration of the proposed thyroid hormone regulation of Mc4r mRNA levels in offspring of HFD dams. Offspring of HFD dams presented with lower POMC (6) and greater plasma T3 concentrations. On reaching the PVN, T3 is transported into the neurons, inducing the association of its receptor to the Mc4r promoter. This association is accompanied by upregulation of H3K27ac and is involved in the downregulation of Mc4r mRNA levels in the offspring of obese dams. ARC, arcuate nucleus; HAT, histone acetyltransferase; αMsh, α-melanocyte–stimulating hormone.