Serum and liver concentrations of AMD and DEA. Rats were treated with AMD (400 mg/kg, ip) and 16 h later with LPS (1.6 × 10⁶ EU/kg, iv) or saline. Blood and tissue samples were collected at 2, 4, 6, or 10 h after LPS injection. Serum concentrations of (A) AMD and (B) DEA and liver concentrations of (C) AMD and (D) DEA were measured with LC/MS/MS as described in “Materials and Methods” section. n = 4–9.