Development of liver injury. Rats were treated with AMD (400 mg/kg, ip) or vehicle and 16 h later with LPS (1.6 × 10⁶ EU/kg, iv) or saline. They were examined 2, 4, 6, or 10 h after LPS injection. Activities of (A) ALT and (B) AST in serum were measured. # indicates significantly different from respective groups not given LPS; * indicates significantly different from respective group not given AMD. p < 0.05, n = 4–9.