Correlations for study measures.

(A) Correlations are shown between percentage reductions from predose concentrations in plasma ACTH and serum 17OHP (N = 193, r = 0.814, P < .05). Correlation between plasma concentration (exposure) of NBI-77860 and plasma or serum concentrations of ACTH (B; r = −0.569, P < .05) and 17OHP (C; r = −0.422, P < .05). All measurements were taken during the early-morning rise of ACTH defined by the increase in all eight subjects and corresponded to the 4- and 6-hour timepoints postdosing (2–4 am) illustrated in Figure 1B.